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Sci Rep: 乡村和城市环境中的儿童和青少年皮肤微生物群模式是不同的

2017-04-27 AlexYang MedSci原创

人类微生物群的组成收到多种因素的影响。理解微生物群的动态对提高人类健康水平是重要的,因为微生物在炎症疾病中的发生有着关键的角色,比如过敏性疾病过敏性鼻炎等。最近,研究人员研究了住在不同环境中275名芬尼斯孩子(几个月大到青少年)双臂的皮肤微生物群。研究人员发现,尽管年龄是一个主要影响皮肤微生物构成的因子,生活环境同样能够区别化城市和乡村孩子的皮肤微生物群。并且,环境的影响具有年龄特异性,在刚学步的

人类微生物群的组成收到多种因素的影响。理解微生物群的动态对提高人类健康水平是重要的,因为微生物在炎症疾病中的发生有着关键的角色,比如过敏性疾病过敏性鼻炎等。

最近,研究人员研究了住在不同环境中275名芬尼斯孩子(几个月大到青少年)双臂的皮肤微生物群。研究人员发现,尽管年龄是一个主要影响皮肤微生物构成的因子,生活环境同样能够区别化城市和乡村孩子的皮肤微生物群。并且,环境的影响具有年龄特异性,在刚学步的孩子中最为明显,在新生儿中不明显,而在青少年中不存在。个人的变化同样与年龄和环境相关。令人惊讶的是,手臂微生物群的变化在乡村中除了青少年之外,其他年龄段的变化较小。研究人员同样收集了血清样本对变应性致敏进行鉴定,结果发现了变应性致敏与微生物构成的一个较弱的但是显着的相关性。最后,研究人员指出,身体的和行为的变化,以及年龄和对环境微生物接触量可以共同影响皮肤微生物群的动态变化,并且也解释了在青少年中皮肤微生物群与生活环境的相关性丢失的原因。

原始出处:

Jenni Lehtimäki, Antti Karkman, Tiina Laatikainen et al. Patterns in the skin microbiota differ in children and teenagers between rural and urban environments. Sci Rep. 31 March 2017. doi:10.1038/srep45651

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    2017-04-29 虈亣靌

    不错的方式,努力学习,刻苦专研,不断总结出来新经验。

    0

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    2017-04-29 虈亣靌

    不错的方式,努力学习,刻苦专研,不断总结出来新经验。

    0

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日前,皮肤学顶级杂志Journal of Investigative Dermatology在线发表了中国科学院-马普学会计算生物学伙伴研究所汪思佳研究组题为:“A genome-wide association study of basal transepidermal water loss (TEWL) finds variants at 9q34.3 to be associated wit

Sci Immunol:皮肤中这类细胞或可抗癌!

在新出版的研究中,达特茅斯诺里斯癌症中心的研究人员发现,称为常驻记忆T细胞的独特免疫细胞,在预防黑素瘤方面表现非常出色。这项工作开始于一个问题——为什么发生自身免疫性疾病(称为白癜风)的黑色素瘤患者有如此好的预后。白癜风是针对正常健康黑色素细胞的自身免疫性皮肤病,导致斑点中皮肤色素沉着丧失。研究小组使用黑色素瘤和白癜风的小鼠模型发现,常驻记忆T细胞永久寄居在受白癜风影响的皮肤中,在那里它们杀死黑素

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