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AP&T:β-2肾上腺素能受体多态性可预测功能性胃肠病

2013-08-06 王姗 编译 cmt

β-2肾上腺素能受体(ADRB2),是疼痛信号传导中的神经递质—肾上腺素的重要靶受体。ADRB2单倍型可影响受体表达和配体反应,并与非GI疾病的疼痛有关。来自美国的V. M. Kushnir、B. Cassell、C. P. Gyawali等人近日发表论文,该研究评价对于功能性胃肠病诊断(FGID)及肠外功能性(EIFD)诊断,ADRB2的基因多态

β-2肾上腺素能受体(ADRB2),是疼痛信号传导中的神经递质—肾上腺素的重要靶受体。ADRB2单倍型可影响受体表达和配体反应,并与非GI疾病的疼痛有关。来自美国的V. M. Kushnir、B. Cassell、C. P. Gyawali等人近日发表论文,该研究评价对于功能性胃肠病诊断(FGID)及肠外功能性(EIFD)诊断,ADRB2的基因多态性(rs1042713, rs1042714)是否具有等位基因风险性,且ADRB2是否可预测GI症状及健康相关生活质量(HRQOL)。研究显示,ADRB2在rs1042714上的小等位基因可预测FGID和EIFD,且可能影响肠道症状及HRQOL。这些发现为交感神经系统在FGID病生理过程中的作用提供了间接证据。该文在线发表于2013年第3期38卷《营养药理学与治疗学》(Alimentary Pharmacology & Therapeutics)杂志上。

398名研究对象(49.6±2.9岁,68.0%为女性)中,170名(42.5%)符合罗马标准Ⅲ中≥1种FGID的标准[IBS(n=139,34.9%);功能性消化不良(FD,n=136,34.1%);功能性胸痛(FCP,n=25,6.2%)],同时288名对象为健康对照。对FGID对象记录其肠道症状的严重程度及累及情况(10-cm VAS)、频率(天数/持续2周)、EIFD、精神疾病诊断及HRQOL(SF 36)。多变量模型确定ADRB2基因多态性对于HRQOL的影响,中介性分析将功能性诊断做为可能的中间事件进行评估。

结果rs1042714小G等位基因与FGID的诊断(OR 1.8;95%CI 1.2-2.7;P=0.009)相关,特别是FD(OR 2.1,95%CI 1.3-3.3);与诊断为IBS(P=0.19)与FCP(P=0.06)的趋势相关。在IBS患者中,G等位基因携带者表现出更为严重的肠道症状(P=0.025)及较长的症状持续天数(P=0.009)。G等位基因携带者中更多人存在EIFD(1.0±0.1 vs. 0.4±0.07,P<0.001),且有较差的HRQOL。FGID、EIFD及精神疾病的诊断在ADRB2对于HRQOL的影响方面有部分介导作用。

原始出处:

Kushnir VM, Cassell B, Gyawali CP, Newberry RD, Kibe P, Nix BD, Sabzpoushan A, Kanuri ND, Sayuk GS.Genetic variation in the beta-2 adrenergic receptor (ADRB2) predicts functional gastrointestinal diagnoses and poorer health-related quality of life.Aliment Pharmacol Ther. 2013 Aug;38(3):313-23

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    2013-08-08 xzw120
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