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Eur Heart J:中年早期人群适度喝酒可降未来心衰风险

2015-01-22 小田 译 医学论坛网

众所周知,酒精具有心脏毒性,如果过多摄入可导致心力衰竭(HF)。但无论是男性还是女性,其适度酒精摄入与心衰风险的关系尚未知。2015年1月20日在线发表于《欧洲心脏杂志》(Eur Heart J)杂志的一项研究回答了上述问题,研究者发现,中年早期人群每周酒精摄入达7杯(98 g酒精)与其将来心衰风险较小有相关性,女性与男性人群的这种相关性相似,但在女性中不十分确定。研究结果进一步表明,尽管过量

众所周知,酒精具有心脏毒性,如果过多摄入可导致心力衰竭(HF)。但无论是男性还是女性,其适度酒精摄入心衰风险的关系尚未知。2015年1月20日在线发表于《欧洲心脏杂志》(Eur Heart J)杂志的一项研究回答了上述问题,研究者发现,中年早期人群每周酒精摄入达7杯(98 g酒精)与其将来心衰风险较小有相关性,女性与男性人群的这种相关性相似,但在女性中不十分确定。研究结果进一步表明,尽管过量摄入酒精的危险性,但如果中年早期适度摄入可能降低心衰风险。

研究者们纳入了 “动脉粥样硬化风险的社区人群”(ARIC)研究中基线无心衰的14 629例受试者,年龄54 ± 6岁,女性占55%,对其随访24 ± 1年。记录其基线时和8.9 ± 0.3年期间累计平均的自我报告每周酒精摄入量(1杯=14 g酒精)。利用多变量Cox比例风险模型评估酒精摄入与心衰的相关性,以及这种相关性是否可被年龄修正。

结果显示,大多数受试者都是戒酒者(42%)或既往喝酒者(19%),其中每周喝7杯、7—14杯和≥14杯的受试者比例分别为25%、8%和3%。发生心衰的男性和女性受试者分别为1271例和1237例。

相对于戒酒者,每周喝7杯酒的男性受试者的心衰风险减少[危险比(HR)为0.80,P= 0.006],这一影响在女性中不太确定(HR 0.84,P = 0.05)。

在喝酒更多的人群中,无论是男性还是女性,其心衰风险的差异并不显著。

喝什么酒有益健康?

既然中年人群适度喝酒有益,那么问题又来了,市场上酒品那么多,喝什么酒才真正有益呢?之前有研究显示,因红酒富含抗氧化剂,保护心血管,从而降低心肌梗死卒中和腹主动脉瘤等风险,还能延缓皮肤等器官的老化。可见,如果您喜欢喝酒,在中年早期适度喝一些红酒或许是个不错的选择。当然,并不是所有人都适合喝酒。下面这些人群无论是何种年龄段,都不适合喝酒,这些人群包括:1、慢性肝病人群,如:慢性病毒性肝炎、酒精性肝病、药物性肝病、脂肪肝等;2、慢性胃病人群;3、已有动脉硬化和血管狭窄人群如果饮红葡萄酒过多,一则不利于供血机能,二则酒精本身会升高血脂和促进动脉硬化。

原始出处:

Gonçalves A1, Claggett B2, Jhund PS3, Rosamond W4, Deswal A5, Aguilar D6, Shah AM2, Cheng S2, Solomon SD7.Alcohol consumption and risk of heart failure: the Atherosclerosis Risk in Communities Study.Eur Heart J. 2015 Jan 19. pii: ehu514. [Epub ahead of print]


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    2015-07-25 1dd82894m82(暂无匿称)

    最可怕的还有慢性姨腺炎!让你生不如死!

    0

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    2015-01-24 zhaojie88
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    2015-01-24 ymljack
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