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Gastroenterology:亚洲早期炎症性肠病流调结果

2016-01-26 Mechront 译 MedSci原创

亚洲炎症性肠病(IBD)的发生率在上升,但是对该地区该疾病的进展认识却很少。始于2011年的关于亚太地区克罗恩病(CD)和溃疡性结肠炎(UC)流行病学研究涉及了中国、香港、印度尼西亚、斯里兰卡、澳门、马来西亚、新加坡、泰国和澳大利亚等区域,研究者目前的研究数据来自这正在进行的研究。研究者纳入了2011-2013年间的413名平均年龄37岁的IBD患者,其中222名UC患者,181名CD患者,10名

亚洲炎症性肠病(IBD)的发生率在上升,但是对该地区该疾病的进展认识却很少。始于2011年的关于亚太地区克罗恩病(CD)和溃疡性结肠炎(UC)流行病学研究涉及了中国、香港、印度尼西亚、斯里兰卡、澳门、马来西亚、新加坡、泰国和澳大利亚等区域,研究者目前的研究数据来自正在进行的研究。

研究者纳入了2011-2013年间的413名平均年龄37岁的IBD患者,其中222名UC患者,181名CD患者,10名IBD未分类患者。研究者分析了患者疾病的过程、严重程度和死亡率。通过Kaplan-Meier分析评估治疗风险。

研究数据显示,CD患者从炎症发展到炎性狭窄或穿透性疾病的累积概率为19.6%;CD患者使用免疫抑制剂或抗肿瘤坏死因子治疗的累积概率分别为58.9%和12%,对于UC患者该数据分别为12.7%和0.9%。肛周CD会增加诊断1年内使用抗肿瘤坏死因子治疗的风险 (HR, 2.97; 95% CI, 1.09-8.09)。CD患者和UC患者诊断1年后手术的累积概率分别为9.1%和0.9%。与炎症性疾病相比,CD和穿透性疾病的患者手术风险增加7倍(HR, 7.67; 95% CI, 3.93-14.96)。IBD患者的整体死亡率是0.7%。

该基于人群的前瞻性研究表明,亚洲的IBD患者期早期疾病情况与西方国家具有可比性;CD患者常会发展为复杂疾病,对免疫抑制剂使用需求不能增加;亚洲早期UC患者手术率很低。认识不同人群IBD的进展可以帮助医疗界优化该疾病的治疗,改善预后。

原始出处:


Ng SC, Zeng Z,et al.Early Course of Inflammatory Bowel Disease in a Population-Based Inception Cohort Study From 8 Countries in Asia and Australia.Gastroenterology. 2016 Jan;150(1):86-95.e3.

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    2016-02-03 许安
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    2016-05-04 1dd8c52fm63(暂无匿称)

    学习啦

    0

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