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Ann Rheum Dis:45岁以下人群中,提示脊柱中轴型脊柱关节炎MRI改变的发生率

2019-11-21 xiangting MedSci原创

这项基于人群的大型研究发现,提示axSpA的炎症和脂肪MRI病变的发生率很高,尤其是脊柱。这表明这种MRI表现对于axSpA的诊断和分类的价值有限。

这项研究目的是在一般人群样本中,探讨脊柱和骶髂关节(SIJMRI提示中轴型脊柱关节炎(axSpA)的骨髓水肿(BME)和脂肪病变(FL)发生率。

作为基于社区研究项目的一部分(波美拉尼亚健康研究),志愿者接受脊柱(矢状位T1/T2)和SIJMRI检查。两名经过校准的阅片人使用国际脊柱关节炎协会评估对图像进行评估,识别提示axSpASIJ和椎体角(VC)中的BMEVC中的FL

对年龄<45793名志愿者(男性占49.4%,平均年龄37.3±6.3岁,人类白细胞抗原-B27 +8.4%)进行了MRI检查。136名参与者(17.2%)存在SIJ BME218名(27.5%)有VC BME645名(81.4%)出现了FL。分别有136名(17.2%)、7名(0.9%)和1名(0.1%)志愿者在≥1≥3≥5SIJ象限出现了SIJ BME。在VC中,分别有218名(27.5%)、38名(4.8%)和6名(0.8%)志愿者存在≥1≥3≥5BME病变,而分别有645名(81.3%)、351名(44.3%)和185名志愿者(23.3%)存在≥1≥3≥5FLLogistic回归分析显示,VC中的BMEFL与年龄增长有关:每增加十年分别为:OR 1.3395CI1.021.72OR 1.7395CI1.322.27

这项基于人群的大型研究发现,提示axSpA的炎症和脂肪MRI病变的发生率很高,尤其是脊柱。这表明这种MRI表现对于axSpA的诊断和分类的价值有限。随着年龄的增长,炎症和脂肪MRI病变发生率升高表明机械因素可能起作用。

原始出处:

Xenofon Baraliakos. Frequency of MRI changes suggestive of axial spondyloarthritis in the axial skeleton in a large population-based cohort of individuals aged <45 years. Ann Rheum Dis. 19 November 2019.

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    2020-01-08 zhmscau
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    2019-11-23 lmm397
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