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Ann Oncol:每天刷牙就能降低头颈癌风险

2016-06-14 Seven L 译 MedSci原创

根据Annals of Oncology发表的回顾性研究结果,保持良好的口腔卫生,可能会降低头颈部癌的风险。研究表明,口腔卫生不好可能增加头颈癌发生风险,但是口腔卫生在头颈部恶性肿瘤的发展中的因果关系一直是不确定的。西奈山伊坎医学院预防医学系的Dana Hashim医学博士和他的同事们对8925名头颈癌患者和12527名无癌症对照患者进行了研究,试图评估头颈部癌症风险和五项口腔卫生指标(戴假牙、相

根据Annals of Oncology发表的回顾性研究结果,保持良好的口腔卫生,可能会降低头颈部癌的风险。

研究表明,口腔卫生不洁可能增加头颈癌发生风险,但是口腔卫生在头颈部恶性肿瘤的发展中的因果关系一直是不确定的。

西奈山伊坎医学院预防医学系的Dana Hashim医学博士和他的同事们对8925名头颈癌患者和12527名无癌症对照患者进行了研究,试图评估头颈部癌症风险和五项口腔卫生指标(戴假牙、相关缺失的牙齿、牙龈疾病、刷牙和牙医的访问)间的联系。

口腔癌、口咽癌、下咽部癌、喉癌和其他口腔/咽癌分别有2858例、2402例、738例、2086例和841例。大多数患者通过面对面问卷调查获得口腔卫生相关数据,还有一项研究中患者的相关数据来自牙医的问卷调查。

数据显示,以下因素与头颈癌风险呈负相关:缺牙小于5科 (OR = 0.78; 95% CI, 0.74-0.82)、每年看牙医(OR = 0.82; 95% CI, 0.78-0.87)、每天至少刷牙一次(OR = 8.3; 95% CI, 0.79-0.88)和没有牙龈疾病(OR = 0.94; 95% CI, 0.89-0.99)。

戴假牙与头颈癌风险的增加无关。

与口腔和咽喉癌风险呈负相关的因素包括缺牙少于5、每天刷牙、定期访问牙医。对于下咽癌 ,每天刷牙、定期访问牙医可以降低癌症风险。

喉癌风险会因缺牙小于5、戴假牙、定期访问牙医和每天刷牙降低,但是当将这些因素全部纳入分析时,联系是衰减的。

研究人员计算了不超过2个良好口腔卫生指标的口腔癌和所有头颈癌的人群归因分数,分别为8.9% (95% CI, 3.3-14)和5.4% (95% CI, 0.36-10)。

研究的局限性包括某些可能影响口腔卫生但研究者无法控制的因素,如糖尿病管理或已存在的炎症性口腔疾病,还有潜在的其他偏倚。

研究结果表明,良好的口腔卫生可以降低头颈癌风险。研究者呼吁人们改善并保持良好的口腔卫生,如每天刷牙、定期访问牙医等,不过研究这也指出,良好口腔卫生对癌症风险的降低程度比较小。

原始出处:


Hashim D, et al.The role of oral hygiene in head and neck cancer: Results from International Head and Neck Cancer Epidemiology (INHANCE) Consortium . Ann Oncol. 2016;doi:10.1093/annonc/mdw224.

Poor oral hygiene contributes to head, neck cancer risk
.Healio.June 13, 2016

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    2016-11-08 minlingfeng
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    2016-10-11 1e10c84am36(暂无匿称)

    好文章,受益

    0

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    2016-08-21 sjq027
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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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    2016-09-12 ylzr123

    赞了!深度好文,深入学习。

    0

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    2016-08-28 ylzr123

    深度好文,值得学习,赞!

    0

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