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JAMA Ophthalmol:富含ω-3脂肪酸的饮食可显著降低糖尿病视网膜病变的发病率

2016-08-21 MedSci MedSci原创

据发表于JAMA Ophthalmol的一项前瞻性观察研究显示,摄入ω3脂肪酸的老年2型糖尿病患者与食用两星期鱼油效果一样可显著降低糖尿病视网膜病变的发病风险。 糖尿病视网膜病变是导致老年人视力丧失的主要原因。其发病机制尚不完全清楚,但炎症、氧化应激和微血管改变在视网膜功能恶化中起着重要作用。视网膜中长链ω3多不饱和脂肪酸的含量很高,而长链ω3多不饱和脂肪酸形成oxylipins,具有抗炎和

据发表于JAMA Ophthalmol的一项前瞻性观察研究显示,摄入ω3脂肪酸的老年2型糖尿病患者与食用两星期鱼油效果一样可显著降低糖尿病视网膜病变的发病风险。

糖尿病视网膜病变是导致老年人视力丧失的主要原因。其发病机制尚不完全清楚,但炎症、氧化应激和微血管改变在视网膜功能恶化中起着重要作用。视网膜中长链ω3多不饱和脂肪酸的含量很高,而长链ω3多不饱和脂肪酸形成oxylipins,具有抗炎和抗血管生成的作用。

该研究共随访了3614名参与西班牙初级卫生保健中心的2型糖尿病患者(平均年龄67岁)来探究加入ω3多不饱和脂肪酸的饮食是否会影响糖尿病视网膜病变的发生率。最终获得3482名参与者的完整数据,中位随访期为六年。

基线时期评估参与者的饮食情况,然后每年使用食物频率问卷和面对面访谈形式调查其饮食情况。此外,研究人员还回顾了所有促使糖尿病视网膜病变发生而需要激光凝固法、玻璃体腔内皮生长因子注射和/或玻璃体视网膜手术治疗的医疗记录。

结果表明,与每天摄入ω3脂肪酸的量少于500毫克的患者相比,每天至少摄入500毫克ω-3脂肪酸饮食的患者其糖尿病视网膜病变的发病风险降低了48%(危险比为0.52(95%可信区间为0.31-0.88);P = 0.001)。

该研究领导者,来自西班牙巴塞罗那医院门诊部的Aleix Sala-Vila说道,“我们的研究结果表明,经常食用鱼油除了可延缓或预防冠状动脉和脑血管的发生及进展外,还可预防动脉床血管疾病的发生及进展。从鱼中获取的长链ω-3脂肪酸有益于该研究队列人群。”

在评论该研究时,来自于丹麦哥本哈根大学的Michael Larsen指出作为一个较大的膳食研究的一部分,这项研究进行了一项探索性的分析,如果结果可以被验证,那么对公众健康的影响将是巨大的,切换至富含ω-3脂肪酸的饮食值得引起公众的注意。

原始出处:

Susan Mayor. Oily fish intake reduces risk of diabetic retinopathy, study shows. BMJ 2016; 354 doi: http://dx.doi.org/10.1136/bmj.i4586.


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    2016-10-13 1e10c84am36(暂无匿称)

    文章真好,喜欢阅读

    0

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  4. 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time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102333, encodeId=39421023335a, content=学习啦,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Mon Aug 22 20:49:00 CST 2016, time=2016-08-22, status=1, ipAttribution=)]
  5. 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href='/topic/show?id=27b290e82f4' target=_blank style='color:#2F92EE;'>#视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7143034078, createdName=zhanfl, createdTime=Tue Aug 23 03:40:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541160, encodeId=e10f15411604a, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Tue Aug 23 03:40:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102333, encodeId=39421023335a, content=学习啦,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Mon Aug 22 20:49:00 CST 2016, time=2016-08-22, status=1, ipAttribution=)]
    2016-09-14 1e10c84am36(暂无匿称)

    文章不错,值得拜读

    0

  6. 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encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jul 27 09:40:00 CST 2017, time=2017-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=126686, encodeId=abdf126686ca, content=文章不错,值得拜读, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 14 14:43:00 CST 2016, time=2016-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269836, encodeId=33ae1269836fb, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Tue Aug 23 03:40:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329874, encodeId=e24113298e450, content=<a href='/topic/show?id=8f3a19290dd' target=_blank style='color:#2F92EE;'>#ω-3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19290, encryptionId=8f3a19290dd, topicName=ω-3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=232a2500033, createdName=1249859em38(暂无昵称), createdTime=Tue Aug 23 03:40:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413873, encodeId=444214138e341, content=<a href='/topic/show?id=27b290e82f4' target=_blank style='color:#2F92EE;'>#视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7143034078, createdName=zhanfl, createdTime=Tue Aug 23 03:40:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541160, encodeId=e10f15411604a, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Tue Aug 23 03:40:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102333, encodeId=39421023335a, content=学习啦,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Mon Aug 22 20:49:00 CST 2016, time=2016-08-22, status=1, ipAttribution=)]
    2016-08-23 zutt
  7. 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  8. 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  9. 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time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102333, encodeId=39421023335a, content=学习啦,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Mon Aug 22 20:49:00 CST 2016, time=2016-08-22, status=1, ipAttribution=)]
  10. 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time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102333, encodeId=39421023335a, content=学习啦,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Mon Aug 22 20:49:00 CST 2016, time=2016-08-22, status=1, ipAttribution=)]
    2016-08-22 医路开来

    学习啦,谢谢

    0

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