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European Radiology:活体肝移植中胆管-管吻合术后胆道狭窄的经皮经肝治疗方法

2022-06-10 shaosai MedSci原创

在活体肝移植(LDLT)中重建胆管时,由于胆管-管吻合术保留了Oddi括约肌并保持了生理上的胆肠连续性,因此比肝空肠吻合术更受欢迎。

肝移植是治疗终末期肝病或小型肝细胞癌(HCC)的标准治疗方法。由于器官的短缺仍然是一个严峻的问题,因此活体肝移植(LDLT)目前被认为是一种可供选择的治愈性治疗方式。在成人LDLT中重建胆管时,由于胆管-管吻合术保留了Oddi括约肌并保持了生理上的胆肠连续性,因此比肝空肠吻合术更受欢迎。然而,与肝空肠吻合术相比,胆管-管吻合术更经常发生胆道狭窄。

近日,发表在European Radiology杂志的一项研究探讨了LDLT中胆管-管吻合术后经皮经肝治疗胆道狭窄的临床效果。

项回顾性研究利用患者的医疗记录和图像,记录每位患者的基线特征、手术细节、临床结果、8个月内引流导管移除率以及导管移除后的复发情况。通过单变量和多变量分析,评估了8个月内引流导管拔除失败和引流导管拔除后胆道狭窄复发的风险因素。 

本研究共评估了112名患者(53.4±8.79岁,91名男性)。75名患者(70.0%)放置了多个引流导管。107名患者(95.5%)成功拔出引流导管。引流导管在8个月内未能移除与肝动脉并发症(p = 0.034)和需要替代通道技术的狭窄(p = 0.034)有关。在1、2、3和5年内,拔除引流导管后的累积初级通畅率分别为85.4%、79.8%、75.8%和68.4%。胆道狭窄的复发与存在未经治疗的孤立扇形管(aHR,3.632;95% CI,1.086-12.150,p = 0.037)和同时存在的胆漏(aHR,2.475;95% CI,1.090-5.621,p = 0.031)有关。 


图 本研究中使用的导管到导管的胆道吻合术的类型

本研究表明,经皮经肝治疗对治疗LDLT中胆管-管吻合术后的胆道狭窄具有很大的临床前景。由于这些患者经常发生多处胆管的狭窄,因此需要进行多次引流以保持胆管畅通。

 

原文出处:

In Joon Lee,Jae Hwan Lee,Seong Hoon Kim,et al.Percutaneous transhepatic treatment for biliary stricture after duct-to-duct biliary anastomosis in living donor liver transplantation: a 9-year single-center experience.DOI:10.1007/s00330-021-08373-z

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