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Stroke:2万人研究发现,兼具糖尿病和抑郁症的中风患者,更容易痴呆,丧失独立能力

2021-01-08 Freeman MedSci原创

兼具糖尿病和抑郁症的中风患者,更容易痴呆,丧失独立能力

 
全世界每年大约有2570万人在急性中风住院治疗后存活下来,这使得越来越多的人患有中风后遗症。18% 的患者在180天内进入长期护理(LTC)或复杂的持续护理。大多数被长期护理中心接纳的人不会回到社区,并有研究表明这些患者的健康相关的生活质量很低。这些以及与之相关的巨大经济负担,表明需要识别高风险患者,并有机会规划支持功能独立的护理结构。
 
大约10% 的初次中风患者在中风后不久就会发展成痴呆症。中风后认知缺陷已被确定为长期功能衰退的重要预测因素,约四分之一的中风存活者进入 长期护理后有严重的认知损害。糖尿病和抑郁症通常同时存在; 抑郁症在有糖尿病的人群中比在无糖尿病的人群中高出2倍,这表明抑郁症是一个普遍的多发病群集。在之前的一项横向研究研究中发现,相对于只有一种或者没有其他疾病的的中风患者,同时患有多种疾病的中风患者(同时有抑郁和糖尿病)的认知分数更低。但对多种共患病的中风患者而言,他们是否更容易痴呆或者接收长期治疗,目前无法仍不清楚。
 
加拿大多伦多大学的Michael Ouk等人,对上述问题进行了探究。他们回顾性分析了2003-2013年期间安大略省的首发脑中风患者。在卒中入院前5年内查明糖尿病和抑郁症的病前病史。同时采集长期护理入院、痴呆事件、中风或短暂性脑缺血发作再入院以及全因死亡率相关数据。
 
结果显示,在23579例中风住院病人中,有20201例重返社区。中位随访时间为5.6年内,糖尿病和抑郁症者和长期护理高度有关( p = 0.02) 。这在妇女中更常见,在患有糖尿病的妇女中,抑郁症的多发病率显示长期护理的入院危险更高(aHR= 1.57)和痴呆(aHR = 1.85)风险更高。
 
在整个队列中,糖尿病和抑郁分别与长期护理入院、痴呆事件相关、中风/TIA再入院和全因死亡率有显著性关系。
 
这个研究的重要意义在于:糖尿病和抑郁同时存在时,患痴呆和中风后需要长期护理的风险在女性中更高高。这提示,长期的卒中恢复策略中,可以从情绪和代谢多发病的角度去降低高危患者的不良事件风险。
 
 
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    2021-01-08 zb1235672

    #糖尿病#学习了!

    0

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    2021-01-08 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2021-01-08 guging

    中风是俗称,应该称为缺血性卒中吧

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1753576, encodeId=f83c1e53576a6, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Tue Sep 21 18:46:37 CST 2021, time=2021-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538099, encodeId=53f5153809978, content=<a href='/topic/show?id=e835226210e' target=_blank style='color:#2F92EE;'>#中风患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22621, encryptionId=e835226210e, topicName=中风患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b5612933772, createdName=sunylz, createdTime=Sat Jan 09 19:46:37 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914695, encodeId=395d914695c2, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=178, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Fri Jan 08 18:40:14 CST 2021, time=2021-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043453, encodeId=101610434537b, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jan 08 07:46:37 CST 2021, time=2021-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046003, encodeId=9a4a10460037b, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Jan 08 07:46:37 CST 2021, time=2021-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048708, encodeId=a3141048e081e, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Jan 08 07:46:37 CST 2021, time=2021-01-08, status=1, ipAttribution=)]
    2021-01-08 junJUN

    老年人痴呆何药可用??

    0

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