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20年研究发现,它能延长糖尿病患者寿命多达8年

2016-10-03 佚名 药明康德

糖尿病患者,如何才能活得更久活得更好?近日,欧洲的科学家发现,专注于在早期对患者全方位强化管理,可使2型糖尿病中老年患者寿命延长8年之久,且在寿命延续期间也没有出现严重并发症。这将激发糖尿病研究领域转向于“老龄健康,延年益寿”策略。相关研究成果发布在欧洲糖尿病研究学会官方期刊《Diabetologia》上。糖尿病是由于人体内糖代谢紊乱而导致的一系列健康问题。它是一种慢性病,波及全球数亿人,而且发病

糖尿病患者,如何才能活得更久活得更好?近日,欧洲的科学家发现,专注于在早期对患者全方位强化管理,可使2型糖尿病中老年患者寿命延长8年之久,且在寿命延续期间也没有出现严重并发症。这将激发糖尿病研究领域转向于“老龄健康,延年益寿”策略。相关研究成果发布在欧洲糖尿病研究学会官方期刊《Diabetologia》上。


糖尿病是由于人体内糖代谢紊乱而导致的一系列健康问题。它是一种慢性病,波及全球数亿人,而且发病率呈逐年升高趋势。WHO统计数据显示,全世界有超过4亿的糖尿病患者,预计到2040年患病人数将上升到6.42亿人。如果得不到有效控制,糖尿病的危害十分严重,可进一步导致心脏病、中风、视网膜病变、肾衰竭、足部神经病变、截肢等严重后果。



▲正常情况与糖尿病对比(图片来源:nextgenerationstemcell)

糖尿病治疗手段可以包括饮食、运动、药物等疗法,这些都是糖尿病研究领域频繁关注的焦点。然而,糖尿病患者可能会碰到过这样的经历:即使上述方法都尝试过后,却并没有达到预期疗效水平。看来,除了治疗手段,糖尿病的治疗时机、策略也非常重要。

在研究中,科学家们评价了对患者采取早期全方位强化管理的策略将如何影响糖尿病患者寿命和生活质量。研究纳入了来自丹麦的160名并发有微量蛋白尿的2型糖尿病患者,他们在研究开始时的平均年龄为55岁,都属于超重人群。这些患者被随机分成两组,一组采取常规处理;另一组则针对所有可能导致并发症或死亡的危险因素,采取全方位强化管理,例如合理的降糖、降压、降脂、预防血栓治疗,以及行为习惯矫正(如健康饮食、运动改变、帮助戒烟)等。

这一研究历时20年。结果发现,相比常规治疗组,强化管理组患者平均多活了8年,心脏病和中风发作时间平均推迟了8年。其中,那些使用了他汀类药物降脂的人群,获益相对更明显。

“对于2型糖尿病患者,若能在并发微量白蛋白尿的早期,及早进行强化干预,包括达标治疗和行为矫正,不仅能让病人活得更久,而且在额外延长的寿命期间,也没有出现可怕的严重并发症,”该研究的通讯作者Oluf Pedersen教授说。他是丹麦哥本哈根大学诺和诺德基金会中心内科和内分泌专家。



▲Oluf Pedersen教授(图片来源:哥本哈根大学官网)

Pedersen博士解释说,糖尿病患者一旦出现微量蛋白尿,可能是发生其他并发症的先兆,这是因为微量蛋白尿往往提示发生了肾损伤,也可能是全身血管损伤的标志。此时,全方位多管强化治疗,便可控制那些已知与并发症或过早死亡相关的可调节性危险因素,包括血糖、血压、胆固醇和甘油三酯水平,以及血栓风险。

纽约蒙特非奥里医疗中心(Montefiore Medical Center) 临床糖尿病中心主任Joel Zonszein博士评论说:“这些结果是令人印象深刻,其包含的关键信息也非常具有指导价值。目前,关于糖尿病治疗理念,我们并没强调一开始就采取全方位多管齐下的强化治疗策略,也没有一开始就强调达标治疗。”

参考资料:
[1] Diabetes study zeroes in on key to healthy aging, longer life
[2] Intensive Type 2 Diabetes Treatment Can Extend Survival: Study

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    2016-10-05 忠诚向上

    好好学习

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:47:31 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140198, encodeId=4d04140198de, content=学习啦,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:47:26 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140095, encodeId=c8d4140095d8, content=好文,谢谢编辑。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Tue Oct 04 19:12:30 CST 2016, time=2016-10-04, status=1, ipAttribution=)]
    2016-10-05 童小孩

    谢谢,学习了

    0

  4. 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    2016-10-05 舒心和人

    感谢分享,糖尿病患者的管理确实需要多管齐下

    0

  5. 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    2016-10-05 刘煜

    学习了谢谢。

    0

  6. 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  7. 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GetPortalCommentsPageByObjectIdResponse(id=140304, encodeId=092114030498, content=谢谢,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Wed Oct 05 08:01:59 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140285, encodeId=fd01140285bb, content=感谢分享,糖尿病患者的管理确实需要多管齐下, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Wed Oct 05 07:37:25 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140270, encodeId=a58b1402e0f7, content=学习了谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Wed Oct 05 06:50:37 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474068, encodeId=708b14e4068c9, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:47:31 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140198, encodeId=4d04140198de, content=学习啦,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:47:26 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140095, encodeId=c8d4140095d8, content=好文,谢谢编辑。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Tue Oct 04 19:12:30 CST 2016, time=2016-10-04, status=1, ipAttribution=)]
    2016-10-04 医路开来

    很新的咨询,,

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1753162, encodeId=90501e5316275, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Tue Oct 04 13:18:00 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140653, encodeId=d6e8140653f2, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Oct 05 22:37:52 CST 2016, time=2016-10-05, status=1, ipAttribution=), 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time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140270, encodeId=a58b1402e0f7, content=学习了谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Wed Oct 05 06:50:37 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474068, encodeId=708b14e4068c9, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Oct 05 05:18:00 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140200, encodeId=7a4414020078, content=很新的咨询,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:47:41 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140199, encodeId=fcd4140199e9, content=谢谢分享,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:47:31 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140198, encodeId=4d04140198de, content=学习啦,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:47:26 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140095, encodeId=c8d4140095d8, content=好文,谢谢编辑。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Tue Oct 04 19:12:30 CST 2016, time=2016-10-04, status=1, ipAttribution=)]
    2016-10-04 医路开来

    谢谢分享,,

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1753162, encodeId=90501e5316275, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Tue Oct 04 13:18:00 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140653, encodeId=d6e8140653f2, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Oct 05 22:37:52 CST 2016, time=2016-10-05, status=1, ipAttribution=), 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time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140270, encodeId=a58b1402e0f7, content=学习了谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Wed Oct 05 06:50:37 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474068, encodeId=708b14e4068c9, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Oct 05 05:18:00 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140200, encodeId=7a4414020078, content=很新的咨询,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:47:41 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140199, encodeId=fcd4140199e9, content=谢谢分享,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:47:31 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140198, encodeId=4d04140198de, content=学习啦,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:47:26 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140095, encodeId=c8d4140095d8, content=好文,谢谢编辑。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Tue Oct 04 19:12:30 CST 2016, time=2016-10-04, status=1, ipAttribution=)]
    2016-10-04 医路开来

    学习啦,,

    0

  10. 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createdName=xue8604, createdTime=Wed Oct 05 05:18:00 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140200, encodeId=7a4414020078, content=很新的咨询,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:47:41 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140199, encodeId=fcd4140199e9, content=谢谢分享,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:47:31 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140198, encodeId=4d04140198de, content=学习啦,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:47:26 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140095, encodeId=c8d4140095d8, content=好文,谢谢编辑。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Tue Oct 04 19:12:30 CST 2016, time=2016-10-04, status=1, ipAttribution=)]
    2016-10-04 医张生

    好文,谢谢编辑。

    0

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