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Br J Haematol:女性需警惕!多次妊娠失败可增加缺血性卒中和心肌梗死的发生风险

2016-07-29 MedSci MedSci原创

近日,来自莱顿大学医学中心的一项新的研究发现表明,妊娠失败可增加年轻女性动脉血栓形成的风险,该研究已发表于British journal of haematology。 研究共纳入了缺血性卒中(IS)或心肌梗死(MI)且至少妊娠一次的女性(18~50岁)与妊娠失败对照组进行对比。计算比值比(OR)值与95%置信区间(CI),校正匹配变量、心血管危险因子、心血管病家族史和存在抗磷脂抗体,以得出

近日,来自莱顿大学医学中心的一项新的研究发现表明,妊娠失败可增加年轻女性动脉血栓形成的风险,该研究已发表于British journal of haematology。

研究共纳入了缺血性卒中(IS)或心肌梗死(MI)且至少妊娠一次的女性(18~50岁)与妊娠失败对照组进行对比。计算比值比(OR)值与95%置信区间(CI),校正匹配变量、心血管危险因子、心血管病家族史和存在抗磷脂抗体,以得出流产次数以及所有类型的妊娠失败(早期流产、晚期流产和死胎)。

结果共纳入了165名IS患者,218名MI患者和743名对照者。与无妊娠失败史的女性相比,多次妊娠失败(≥3)的女性动脉血栓的发生风险为其2倍(OR为2.37,95% CI 0.99~5.70),与有死胎史的女性相似(OR为1.68,95%CI 0.79~3.55)。与MI(分别为OR为2.04,95%CI 0.71~5.86和 1.04,95%CI 0.39~2.79)相比,IS相对风险均较高(分别为OR为3 .51,95% CI 1 . 08~11 .35和2.06, 95%CI 0.81~5.23)。

校正抗磷脂抗体并不会影响结果。多胎妊娠失败和死胎可增加IS的发生风险,小程度增加MI的发生风险,考虑了其他心血管危险因素和抗磷脂抗体后,仍可发现此关联。

原始出处:

Maino A, Siegerink B,  et al., Pregnancy loss and risk of ischaemic stroke and myocardial infarction. Br J Haematol. 2016 Jul;174(2):302-9. doi: 10.1111/bjh.14043. Epub 2016 Apr 7.

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    2016-10-03 changfy
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    2016-08-07 biyefy

    在现代社会,这个值得研究

    0

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    2016-07-31 fengyi812
  6. [GetPortalCommentsPageByObjectIdResponse(id=2008229, encodeId=ce162008229f4, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Mon Oct 03 01:48:00 CST 2016, time=2016-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806104, encodeId=d8c11806104c7, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Apr 25 15:48:00 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892784, encodeId=f8481892e843e, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Tue Dec 20 01:48:00 CST 2016, time=2016-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96614, encodeId=983b96614dd, content=在现代社会,这个值得研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMZLw3QSPusicYXZS9YJbN5RyFl9aeicv3rZnKk3RlOx7MKgBiaQd3tf4QiaLhYuCFoqicPcPvGpw8ibZ0zlEl8z0rYfPG/0, createdBy=e50c1932697, createdName=biyefy, createdTime=Sun Aug 07 07:33:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317256, encodeId=e9f5131e25602, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Sun Jul 31 13:48:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95264, encodeId=4d8395264f3, content=为了孩子,为了国家,感谢母亲, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 11:34:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95216, encodeId=2a2f952161a, content=警惕警惕, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Jul 31 11:13:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95130, encodeId=fa5b95130e4, content=学习新知识。, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Jul 30 11:04:00 CST 2016, time=2016-07-30, status=1, ipAttribution=)]
    2016-07-31 onetree

    为了孩子,为了国家,感谢母亲

    0

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    2016-07-31 oo902

    警惕警惕

    0

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    2016-07-30 刘煜

    学习新知识。

    0

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