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JAMA Neurol:血肿扩大的脑出血患儿需紧急治疗

2014-01-10 高晓方 译 医学论坛网

美国一项研究表明,脑内出血患儿可出现血肿扩大并可能需要紧急治疗;在血肿较大及颅内压升高患儿中应考虑重复CT检查。论文12月2日在线发表于《美国医学会杂志·神经病学》(JAMA Neurol)。 此项前瞻性观察队列研究以≥37孕周~18岁的非创伤性脑内出血患儿为受试者,28天以下新生儿和孤立性脑室内出血患儿被排除在外。将48小时内行2次头颅CT扫描评估血肿扩大的患儿与仅行1次CT

美国一项研究表明,脑内出血患儿可出现血肿扩大并可能需要紧急治疗;在血肿较大及颅内压升高患儿中应考虑重复CT检查。论文12月2日在线发表于《美国医学会杂志·神经病学》(JAMA Neurol)。【原文下载】 

此项前瞻性观察队列研究以≥37孕周~18岁的非创伤性脑内出血患儿为受试者,28天以下新生儿和孤立性脑室内出血患儿被排除在外。将48小时内行2次头颅CT扫描评估血肿扩大的患儿与仅行1次CT扫描者相比较。

结果显示,在73例患儿中41例(56%)符合纳入标准,其中22例(30%)行2次头颅CT扫描评估血肿扩大。在上述22例患儿中,症状出现至首次CT检查的中位时间为2小时。中位基线出血量为19.5 mL,脑容积的1.6%。7例患儿出现血肿扩大(32%)。中位扩大为4 mL(四分位容量范围1-11 mL)。3例患儿出现显著(>33%)扩展,2例需要紧急血肿清除。血肿扩大与不良转归无相关性。与仅行1次头颅扫描者相比,2次扫描者的基线出血量更大(P=0.05),并且更有可能因颅内压升高而接受治疗(P<0.001)。

原文出处:

Beslow LA, Ichord RN, Gindville MC, Kleinman JT, Bastian RA, Smith SE, Licht DJ, Hillis AE, Jordan LC.Frequency of Hematoma Expansion After Spontaneous Intracerebral Hemorrhage in Children.JAMA Neurol. 2013 Dec 2. doi: 10.1001/jamaneurol.2013.4672.【原文下载】 


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