Mol Psych：不良的情绪能诱导机体出现炎性

2016-01-02 MedSci MedSci原创

最近，一项发表在Molecular Psychiatry杂志上的研究论文指出，实验性的情绪诱导或可改变白介素18（IL-18）的水平，而且这种实验性情绪诱导也和中央阿片样的神经传递的改变直接相关。来自德克萨斯大学的研究者Alan R. Prossin指出，我们在严重抑郁障碍（MDD）患者机体中发现μ-阿片样受体和机体基准IL-18的水平之间存在强烈的相关性，而我们假设，实验性的情绪诱导会改变IL-

最近，一项发表在Molecular Psychiatry杂志上的研究论文指出，实验性的情绪诱导或可改变白介素18（IL-18）的水平，而且这种实验性情绪诱导也和中央阿片样的神经传递的改变直接相关。

来自德克萨斯大学的研究者Alan R. Prossin指出，我们在严重抑郁障碍（MDD）患者机体中发现μ-阿片样受体和机体基准IL-18的水平之间存在强烈的相关性，而我们假设，实验性的情绪诱导会改变IL-18的水平；随后研究者研究了实验性的情绪诱导对机体血浆中IL-18水平的影响，同时还在28个健康或MDD患者中检测了实验性的情绪诱导和中央阿片样神经传递之间的关联性。

研究者发现，情绪诱导会影响IL-18的水平(P < 0.001)，悲伤的情绪会增加IL-18的水平（p=0.01）；中性的情绪则会降低IL-18的水平（P < 0.001）；而且IL-18水平的改变在抑郁症患者的机体中表现尤为明显（p=0.03），而且IL-18的水平和通过悲伤诱导的μ-阿片样受体的激活之间呈现线性正比的关系。

本文研究数据阐明了促炎性因子IL-18和μ-阿片样神经传递之间的动态关联，未来研究中研究人员想通过深入的研究来检测包括IL-18在内的神经免疫相互作用对于增强抑郁症患者疾病易感性的作用和角色。而且本文研究对于深入剖析严重抑郁障碍发生的机制提供了新的线索和思路。

原始出处：

Prossin AR, Koch AE, Campbell PL, Barichello T, Zalcman SS, Zubieta JK.Acute experimental changes in mood state regulate immune function in relation to central opioid neurotransmission: a model of human CNS-peripheral inflammatory interaction. Mol Psychiatry. 2015 Aug 18. doi: 10.1038/mp.2015.110.

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2016-01-04 pharmxing

简单了点

130 0
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2016-01-04 田田1746

对

131 0
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2016-01-03 lu2996

很多疾病均与情绪有关

143 0
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2016-01-03 lu2996

但是缺乏具体机制

151 0
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2016-01-03 lu2996

学习中

128 0
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2016-01-03 lu2996

支持

96 0
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2016-01-02 sundyli

炎症无处不在

105 0
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2016-01-02 wzf990214

不错的

108 0
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2016-01-02 wzf990214

可以

93 0
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2016-01-02 wzf990214

有意思

106 0

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