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全球首例 女移植儿时冷冻卵巢组织产子

2015-06-10 陈怡君 译 中央通讯社

比利时医师今天表示,他们替1名妇女重植儿时因疾病治疗而切除的卵巢组织后,这名妇女恢复生殖能力、产下1名健康男婴,创下全球先例。法新社报导,这名在刚果共和国出生的女性,5岁时诊断出镰型血球贫血症,11岁搬到比利时,医师发现她罹患的血液遗传疾病已严重到需要骨髓移植。但骨髓移植需要化学治疗或放射治疗来抑制病人的免疫系统,以预防外来植入的造血干细胞受到排斥。根据英国「卫报」(The Guardian),这



比利时医师今天表示,他们替1名妇女重植儿时因疾病治疗而切除的卵巢组织后,这名妇女恢复生殖能力、产下1名健康男婴,创下全球先例。

法新社报导,这名在刚果共和国出生的女性,5岁时诊断出镰型血球贫血症,11岁搬到比利时,医师发现她罹患的血液遗传疾病已严重到需要骨髓移植。但骨髓移植需要化学治疗或放射治疗来抑制病人的免疫系统,以预防外来植入的造血干细胞受到排斥。

根据英国「卫报」(The Guardian),这名患者13岁时,医师在展开化疗前切除她右边卵巢并切片冷冻,目的是为了有朝一日让她成为母亲作准备。当时这名患者还没有月经。

约10年后,医师解冻部分卵巢组织并为她进行移植手术,恢复患者生殖能力。患者27岁时顺利怀孕,并于2014年11月产下3100公克的健康小男婴。

这名患者的卵巢目前维持正常功能,还有部分卵巢组织切片仍受冷冻保存。

根据这篇发表在「人类生殖」(Human Reproduction)期刊的研究,世界上有多名宝宝是经由移植成年女子身上所切除的卵巢组织而出生,但最新这起案例的卵巢是在患者青春期前即切除,创下全球先河。

布鲁塞尔自由大学(Brussels Free University)伊拉斯莫医院(Erasmus Hospital)的德米史提尔(Isabelle Demeestere)医师说:「这是该领域的重大突破,因为儿童病患未来会是这项治疗的最大受益者。」

手术团队主持人德米史提尔说:「当儿童病患需要接受可能破坏卵巢功能的治疗时,冷冻卵巢组织可能是目前唯一保存生育能力的选项。」

原始出处:

Isabelle Demeestere1,2,*, Philippe Simon3, Laurence Dedeken4, Federica Moffa1,6, Sophie Tsépélidis1,2,7, Cecile Brachet5, Anne Delbaere1,2, Fabienne Devreker1,5 and Alina Ferster4.Live birth after autograft of ovarian tissue cryopreserved during childhood. Hum.Reprod.June 9, 2015.doi: 10.1093/humrep/dev128

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    2015-06-16 cooco
  2. [GetPortalCommentsPageByObjectIdResponse(id=1650166, encodeId=45cc165016646, content=<a href='/topic/show?id=9b5a311e2f4' target=_blank style='color:#2F92EE;'>#冻卵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31172, encryptionId=9b5a311e2f4, topicName=冻卵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d81523977587, createdName=cooco, createdTime=Tue Jun 16 03:57:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033341, encodeId=a1ff2033341a5, content=<a href='/topic/show?id=09bf29564b2' target=_blank style='color:#2F92EE;'>#全球首例#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29564, encryptionId=09bf29564b2, topicName=全球首例)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Sun May 08 22:57:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32411, encodeId=b4c43241144, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Sun Jul 12 13:51:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29045, encodeId=3d2729045dd, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Thu Jun 25 18:57:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27201, encodeId=66b32e201c8, content=科技太好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Thu Jun 11 21:22:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26926, encodeId=9b362692674, content=这个可以有, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Wed Jun 10 18:53:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26920, encodeId=34b326920f0, content=棒棒哒!, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f861627568, createdName=aa520612, createdTime=Wed Jun 10 17:49:00 CST 2015, time=2015-06-10, status=1, ipAttribution=)]
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    2015-07-12 zm0805

    ?

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1650166, encodeId=45cc165016646, content=<a href='/topic/show?id=9b5a311e2f4' target=_blank style='color:#2F92EE;'>#冻卵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31172, encryptionId=9b5a311e2f4, topicName=冻卵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d81523977587, createdName=cooco, createdTime=Tue Jun 16 03:57:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033341, encodeId=a1ff2033341a5, content=<a href='/topic/show?id=09bf29564b2' target=_blank style='color:#2F92EE;'>#全球首例#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29564, encryptionId=09bf29564b2, topicName=全球首例)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Sun May 08 22:57:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32411, encodeId=b4c43241144, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Sun Jul 12 13:51:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29045, encodeId=3d2729045dd, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Thu Jun 25 18:57:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27201, encodeId=66b32e201c8, content=科技太好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Thu Jun 11 21:22:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26926, encodeId=9b362692674, content=这个可以有, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Wed Jun 10 18:53:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26920, encodeId=34b326920f0, content=棒棒哒!, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f861627568, createdName=aa520612, createdTime=Wed Jun 10 17:49:00 CST 2015, time=2015-06-10, status=1, ipAttribution=)]
    2015-06-25 zm0805

    0

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    2015-06-11 18619c0a62m

    科技太好了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1650166, encodeId=45cc165016646, content=<a href='/topic/show?id=9b5a311e2f4' target=_blank style='color:#2F92EE;'>#冻卵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31172, encryptionId=9b5a311e2f4, topicName=冻卵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d81523977587, createdName=cooco, createdTime=Tue Jun 16 03:57:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033341, encodeId=a1ff2033341a5, content=<a href='/topic/show?id=09bf29564b2' target=_blank style='color:#2F92EE;'>#全球首例#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29564, encryptionId=09bf29564b2, topicName=全球首例)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Sun May 08 22:57:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32411, encodeId=b4c43241144, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Sun Jul 12 13:51:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29045, encodeId=3d2729045dd, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Thu Jun 25 18:57:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27201, encodeId=66b32e201c8, content=科技太好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Thu Jun 11 21:22:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26926, encodeId=9b362692674, content=这个可以有, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Wed Jun 10 18:53:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26920, encodeId=34b326920f0, content=棒棒哒!, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f861627568, createdName=aa520612, createdTime=Wed Jun 10 17:49:00 CST 2015, time=2015-06-10, status=1, ipAttribution=)]
    2015-06-10 Messichen1992

    这个可以有

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1650166, encodeId=45cc165016646, content=<a href='/topic/show?id=9b5a311e2f4' target=_blank style='color:#2F92EE;'>#冻卵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31172, encryptionId=9b5a311e2f4, topicName=冻卵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d81523977587, createdName=cooco, createdTime=Tue Jun 16 03:57:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033341, encodeId=a1ff2033341a5, content=<a href='/topic/show?id=09bf29564b2' target=_blank style='color:#2F92EE;'>#全球首例#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29564, encryptionId=09bf29564b2, topicName=全球首例)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Sun May 08 22:57:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32411, encodeId=b4c43241144, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Sun Jul 12 13:51:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29045, encodeId=3d2729045dd, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Thu Jun 25 18:57:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27201, encodeId=66b32e201c8, content=科技太好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Thu Jun 11 21:22:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26926, encodeId=9b362692674, content=这个可以有, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Wed Jun 10 18:53:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26920, encodeId=34b326920f0, content=棒棒哒!, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f861627568, createdName=aa520612, createdTime=Wed Jun 10 17:49:00 CST 2015, time=2015-06-10, status=1, ipAttribution=)]
    2015-06-10 aa520612

    棒棒哒!

    0

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