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JAMA Neurol:伴癫痫发作的阿尔茨海默症患者更早出现轻度认知功能障碍

2013-07-18 cherry_ef2002 dxy

根据JAMA Neurology的一篇报道,对于存在遗忘型轻度认知功能损害(aMCI)或阿尔茨海默病(AD)的患者,伴有癫痫发作者出现认知功能减退要早于无癫痫者。根据研究背景可知,AD可增加患者的癫痫发作风险。与无癫痫的AD患者相比,伴有癫痫的AD患者其认知损害更显著,症状进展更快,且尸检发现其神经元缺失更严重。加利福尼亚州旧金山市格莱斯顿神经疾病研究所的Keith A(医学博士,理学硕士)及其同

根据JAMA Neurology的一篇报道,对于存在遗忘型轻度认知功能损害(aMCI)或阿尔茨海默病(AD)的患者,伴有癫痫发作者出现认知功能减退要早于无癫痫者。

根据研究背景可知,AD可增加患者的癫痫发作风险。与无癫痫的AD患者相比,伴有癫痫的AD患者其认知损害更显著,症状进展更快,且尸检发现其神经元缺失更严重。加利福尼亚州旧金山市格莱斯顿神经疾病研究所的Keith A(医学博士,理学硕士)及其同事在研究报道中提到:“与AD相关的癫痫活动值得我们更加的关注,因为这会对患者产生有害影响,并且极易因未能识别而未加治疗,同时还能够反映出影响AD其他方面的病理过程。”

这一研究入组了54名患者,其中12例诊断为aMCI同时伴有癫痫,35例为AD同时伴有癫痫,7例为AD同时存在亚临床癫痫样活动。根据其研究结果,与不伴有癫痫的aMCI患者相比,同时存在癫痫的aMCI患者出现认知功能减退症状的年龄要提早6.8年(64.3岁vs 71.1岁)。与不伴有癫痫的AD患者相比,同时存在癫痫的AD患者出现认知功能减退症状的年龄要提早5.5年(64.8岁vs 70.3岁)。

研究最终认为,对癫痫进行仔细地检查并予以治疗,或可使此类患者的临床病程得到改善。


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    2013-08-26 yinhl1978
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    2013-08-12 li

    really?

    0

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