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JAHA：抗-丙二醛IgM抗体是心血管疾病的保护性标志！

2016-12-21 haofan MedSci原创

抗-丙二醛IgM抗体心血管疾病
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由此可见，抗-丙二醛IgM抗体是心血管疾病的保护性标志，这一发现可能具有诊断和治疗意义。

丙二醛是在脂质过氧化变成氧化型低密度脂蛋白过程中产生的，但是在临床研究中氧化型低密度脂蛋白的抗体出现了不同的研究结果。近日，心血管病领域权威杂志JAHA上发表了一篇研究文章，研究人员旨在研究与抗结合人血清白蛋白丙二醛IgM抗体相关的心血管疾病的风险。

研究者对来自于斯德哥尔摩县之前进行过心血管危险因素筛查的60岁男性和女性（2039名男性，2193名女性）进行了5至7年的随访，研究人员通过ELISA检测了209名心血管事件患者（定义为新的冠状动脉心脏病、致命性和非致命性心肌梗死、缺血性卒中和因心绞痛住院事件）和620名年龄和性别匹配的对照者血清中抗-丙二醛IgM抗体。使用蛋白质组学从头测序方法进行抗体肽/蛋白鉴定。

对吸烟、体量指数、2型糖尿病、高脂血症和高血压进行调整后，抗-丙二醛IgM水平在第10百分分位数以下和第25百分位数以下的患者中可以观察到心血管风险增加（比值比和95%可信区间分别为：2.0；1.19-3.36和1.67；1.16-2.41）。抗-丙二醛IgM水平高于第66百分位数的患者与降低的心血管疾病风险相关（比值比为0.68；95%可信区间为0.48-0.98）。根据性别进行分层，这种相关性只存在于男性中。在病例组中抗-丙二醛IgM水平较低（中位数[间距范围]：141[112.7-164.3]vs. 147.4[123.5-169.6]；P=0.0177），在男性中更为明显（130.6[107.7-155.3] vs. 143.0 [120.1-165.2]；P=0.001）。抗-丙二醛IgM抗体可变区分布明显不同，并且其内容（与少数肽密切相关）比对照抗体（不结合MDA）更具有同源性。

由此可见，抗-丙二醛IgM抗体是心血管疾病的保护性标志，这一发现可能具有诊断和治疗意义。

原始出处：December 20, 2016

Divya Thiagarajan, et al. Human IgM Antibodies to Malondialdehyde Conjugated With Albumin Are Negatively Associated With Cardiovascular Disease Among 60-Year-Olds. JAHA. December 20, 2016.


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    2018-10-15 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=349455, encodeId=c562349455d9, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon Oct 15 22:01:30 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700371, encodeId=b56a1e00371d0, content=<a href='/topic/show?id=a40c9525be' target=_blank style='color:#2F92EE;'>#IgM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9525, encryptionId=a40c9525be, topicName=IgM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e80a30065003, createdName=yhy100210, createdTime=Thu Jan 12 10:47:00 CST 2017, time=2017-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267358, encodeId=7a06126e35868, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Dec 23 12:47:00 CST 2016, time=2016-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498104, encodeId=01d3149810411, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Fri Dec 23 12:47:00 CST 2016, time=2016-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164817, encodeId=fe2616481e72, content=文章很好，值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Dec 22 08:25:28 CST 2016, time=2016-12-22, status=1, ipAttribution=)]
    2017-01-12 yhy100210

    #IgM#

    0

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    2016-12-23 zhaohui6731

    #AHA#

    0

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    2016-12-23 智慧医人

    #血管疾病#

    0

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    2016-12-22 1e10c84am36(暂无匿称)

    文章很好，值得学习

    0

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