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Diabetes Care:接受适当预防性治疗的无冠心病患者有无糖尿病心肌梗死风险相似!

2017-06-10 xing.T MedSci原创

在真实世界的人群中,糖尿病患者采用他汀类药物和阿司匹林治疗率较高,与血管造影没有显著CAD和没有糖尿病的患者具有同样的心血管事件风险。

糖尿病患者的心肌梗死(MI)风险高于无糖尿病患者。因此,对于糖尿病患者和缺血性心脏病危险因素推荐预防性治疗。近日,糖尿病领域权威杂志Diabetes Care上发表了一研究文章,研究人员旨在评估冠状动脉造影(CAG)后有无冠心病并且伴有或不伴有糖尿病的患者发生不良心脏事件的风险。

在丹麦西部的心注册中心登记的患者组成了人群为基础的队列,这些患者在2003年1月1日至2012年12月31日期间接受了CAG检查,并根据有无阻塞性冠心病和糖尿病进行分层。该研究的终点为死亡、心源性死亡和心肌梗死。研究人员计算了未调整和调整后的率比(RRs),以非糖尿病和非CAD患者作为参考组。

研究人员纳入了93866例患者,其中,有12544例(13.4%)患者在进行CAG时患有糖尿病。中位随访时间为4.1年。患有和无糖尿病且无阻塞性冠心病患者具有相同的调整后死亡(RR为1.03(95%可信区间为0.92-1.15))和心源性死亡(RR为1.21(95%可信区间为0.90-1.64))以及MI(RR为0.88(95%可信区间为0.65-1.17))风险。没有CAD的糖尿病患者比没有糖尿病和冠心病的患者更容易接受他汀类药物(75.3% vs. 46%)和阿司匹林(65.7% vs. 52.7%)治疗。

在真实世界的人群中,糖尿病患者采用他汀类药物和阿司匹林治疗率较高,与血管造影没有显著CAD和没有糖尿病的患者具有同样的心血管事件风险。

原始出处:

Kevin K.W. Olesen,et al.Patients With and Without Diabetes Without Significant Angiographic Coronary Artery Disease Have the Same Risk of Myocardial Infarction in a Real-World Population Receiving Appropriate Prophylactic Treatment.Diabetes Care 2017 Jun;https://doi.org/10.2337/dc16-2388

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    2017-06-11 杨利洪

    学习了分享了

    0

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    2017-06-10 flysky120

    糖尿病的慢性并发症

    0

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    2017-06-10 惠映实验室

    疾病并发症确实很复杂,学习的路还是很漫长。

    0

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