Neurology：Lewy体痴呆的一个新的潜在的生物标志物！

2017-07-01 xing.T MedSci原创

在自主皮肤神经中，p-syn是DLB诊断的敏感性生物标志物，有助于区分DLB与其他形式的痴呆症，虽然这需要在一个更大型、更具有代表性的样本中进行证实；另外，皮肤自主神经病变是DLB病的一部分，可能有助于自主神经症状。该研究提供了III级证据表明皮肤活检中皮肤神经纤维的p-syn能够精确区分DLB与其他形式的痴呆。

近日，神经病学领域权威取杂志Neurology上发表了一篇研究文章，研究人员旨在探讨（1）磷酸化α-突触核蛋白（p-syn）在皮肤神经中的沉积是否可以用来从不同形式的痴呆中鉴别出Lewy体痴呆（DLB）；以及（2）小纤维神经病变（SFN）是否与DLB相关。

研究人员分析了18名极具特征的DLB患者（11例植物神经功能紊乱患者）、23例非突触核蛋白病痴呆（NSD；13例早发阿尔茨海默病性痴呆、6例额颞叶痴呆、4例血管性痴呆）和25名健康对照者。所有参与者均进行皮肤活检从近端（即颈部）和远端（即大腿和小腿远端）位置的活检，来研究小神经纤维和p-syn沉积，考虑为α-突触核蛋白的病理形态。

研究人员在所有NSD患者和对照者的任何皮肤样本中均没有检测到p-syn，但在所有DLB患者中均检测到了p-syn。在DLB和皮肤自主去神经病患者中p-syn沉积比较自主神经功能障碍的患者更加严重。

在自主皮肤神经中，p-syn是DLB诊断的敏感性生物标志物，有助于区分DLB与其他形式的痴呆症，虽然这需要在一个更大型、更具有代表性的样本中进行证实；另外，皮肤自主神经病变是DLB病的一部分，可能有助于自主神经症状。该研究提供了III级证据表明皮肤活检中皮肤神经纤维的p-syn能够精确区分DLB与其他形式的痴呆。

原始出处：

Vincenzo Donadio, et al. A new potential biomarker for dementia with Lewy bodies Skin nerve α-synuclein deposits. Neurology. 2017. http://www.neurology.org/content/early/2017/06/30/WNL.0000000000004146.short

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2017-07-04 yinhl1978

#Neurol#

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2018-01-26 智慧医人

#标志物#

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2017-07-03 meiliwuxian

学习一下

91 0
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2017-07-03 zhu_jun9842

#生物标志#

60 0
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2017-07-03 zhu_jun9842

#生物标志#

101 0
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2017-07-02 ann y

Lewy体痴呆的一个新的潜在的生物标志物

100 0
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2017-07-01 海棠胜雪

学习了

119 0
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2017-07-01 天涯183

非常好的文章，学习了，很受益

114 0
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2017-07-01 ren1mw

学习一下吧！学习一下！

106 0
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2017-07-01 1e1a50a1m36(暂无匿称)

在DLB和皮肤自主去神经病患者中p-syn沉积比较自主神经功能障碍的患者更加严重。

81 0