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Ann Surg:为期10年的乳腺癌肿瘤术后结局的研究

2017-05-06 MedSci MedSci原创

肿瘤外科手术(OPS)将广泛的肿瘤切除术与乳房成形术技术相结合,从而将乳房保留手术扩展至可能进行乳房切除术的大型肿瘤。目前,关于这些较大肿瘤的乳腺保留手术的肿瘤学结果的数据很少。近期,一项发表在杂志Ann Surg上的研究旨在评估OPS后的长期肿瘤学结果。此项研究从2004年1月至2016年3月共收集了350个乳腺肿瘤成形术患者的数据。乳房重塑包括减少乳房成形术与皮肤切除(2级肿瘤塑形技术)的患者

肿瘤外科手术(OPS)将广泛的肿瘤切除术与乳房成形术技术相结合,从而将乳房保留手术扩展至可能进行乳房切除术的大型肿瘤。目前,关于这些较大肿瘤的乳腺保留手术的肿瘤学结果的数据很少。


近期,一项发表在杂志Ann Surg上的研究旨在评估OPS后的长期肿瘤学结果。

此项研究从2004年1月至2016年3月共收集了350个乳腺肿瘤成形术患者的数据。乳房重塑包括减少乳房成形术与皮肤切除(2级肿瘤塑形技术)的患者纳入研究。

此项研究结果显示:组织学亚型为:浸润性导管癌219例(62.6%),原位导管癌(DCIS)88例(25.1%),侵袭性小叶癌43例(12.3%)。侵袭性癌症的73例(27.9%)接受新辅助化疗。平均切除的重量为177克。平均病理肿瘤大小为26mm(范围0-180mm),对于侵袭性肿瘤的变化为23mm(4-180mm),而DCIS的变化为32mm(0-100mm)。

12.6%的病例涉及样品边缘浸润;10.5%为浸润性导管,14.7%为DCIS,20.9%为侵入性小叶。
总体乳腺保存率为92%,从DCIS的87.4%变化到侵袭性癌症的93.5%。三十一名患者(8.9%)发生一次或多次术后并发症,导致4.6%的患者术后治疗延迟。中位随访时间为55个月。累积的5年局部、区域和远处复发率分别为2.2%,1.1%和12.4%。

此项研究表明:肿瘤性乳房切除术允许具有自由边缘的广泛切除,并且可用于较大的癌症。

原始出处:
Clough KB, van la Parra RFD, et al. Long-term Results After Oncoplastic Surgery for Breast Cancer: A 10-year Follow-up. Ann Surg. 2017 Apr 26. doi: 10.1097/SLA.0000000000002255.

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    2017-05-13 七堇

    乳房切除,真能彻底杜绝乳腺癌的发生?

    0

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    2017-05-11 虈亣靌

    优秀资料,学习了。

    0

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    2017-05-10 lou.minghong

    学习

    0

  4. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sun May 07 07:44:01 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-09 大爰

    研究的不错学习并分享:

    0

  5. 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    2017-05-07 杨帆7792

    说的云里雾里

    0

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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sun May 07 07:44:01 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 dhzzm

    学习了分享了,很好

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun May 07 09:13:26 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194885, encodeId=927e19488575, content=感说不是很明了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5gJeAA33pg8XSpMyoXQLg4TTWfCC26g4ibkFFUdQVBtofBwAITTWib8S4f1bKDLaYsKVz2KtVfhLQJoia5mISjlibk/0, createdBy=28331949612, createdName=1e10eabem79(暂无匿称), createdTime=Sun May 07 08:05:40 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194870, encodeId=e1741948e031, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sun May 07 07:44:01 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 luominglian113

    受益了,谢谢分享

    0

  8. 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authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun May 07 12:18:17 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194979, encodeId=c8071949e909, content=受益了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun May 07 11:16:59 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194924, encodeId=6fa51949245e, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun May 07 09:13:26 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194885, encodeId=927e19488575, content=感说不是很明了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5gJeAA33pg8XSpMyoXQLg4TTWfCC26g4ibkFFUdQVBtofBwAITTWib8S4f1bKDLaYsKVz2KtVfhLQJoia5mISjlibk/0, createdBy=28331949612, createdName=1e10eabem79(暂无匿称), createdTime=Sun May 07 08:05:40 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194870, encodeId=e1741948e031, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sun May 07 07:44:01 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 天涯183

    非常好的文章,学习了,很受益

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun May 07 09:13:26 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194885, encodeId=927e19488575, content=感说不是很明了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5gJeAA33pg8XSpMyoXQLg4TTWfCC26g4ibkFFUdQVBtofBwAITTWib8S4f1bKDLaYsKVz2KtVfhLQJoia5mISjlibk/0, createdBy=28331949612, createdName=1e10eabem79(暂无匿称), createdTime=Sun May 07 08:05:40 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194870, encodeId=e1741948e031, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sun May 07 07:44:01 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 1e10eabem79(暂无匿称)

    感说不是很明了

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun May 07 09:13:26 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194885, encodeId=927e19488575, content=感说不是很明了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5gJeAA33pg8XSpMyoXQLg4TTWfCC26g4ibkFFUdQVBtofBwAITTWib8S4f1bKDLaYsKVz2KtVfhLQJoia5mISjlibk/0, createdBy=28331949612, createdName=1e10eabem79(暂无匿称), createdTime=Sun May 07 08:05:40 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194870, encodeId=e1741948e031, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sun May 07 07:44:01 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 医艺依意

    学习了,谢谢分享

    0

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额外添加吉西他滨的以蒽环类及紫杉类为基础的化疗在延长早期乳腺癌的无病生存期方面无长期统计学差异

Cancer Epidem Biomar Prev:饮酒会增加乳腺癌的患病风险吗?

近年来,乳腺癌人数不断攀升,究竟是什么导致这一结果呢?最近,一项新的研究指明了饮酒与女性乳腺癌之间的关系,饮酒是乳腺癌风险增加的一大因素,下次还想再来一杯的时候,请仔细考虑一下吧!

Sci Rep:草莓或可预防乳腺癌

意大利马尔凯理工大学最近发表在《科学》杂志上的一项研究称,草莓还能抑制乳腺癌细胞的生长。

Nat Commun:胸部大小与乳腺癌:大胸女性更危险?

胸部大小与乳腺癌的关系——这个“喜闻乐见”的话题一直广受医生和科学家们关注。从1950年开始,关于这一话题的论文已经发表了数百篇,科研界仍莫衷一是。但多数研究认为,胸部大小与乳腺癌发生率和死亡率正相关。2014年,多伦多大学的 M.H.布郎(M.H. Brown)教授和他的同事们在《整形外科与美容外科杂志》(Journal of Plastic, Reconstructive & Ae

JCO:内分泌辅助治疗乳腺癌

研究人员主导的4,724例早期乳腺癌绝经后患者的研究(临床试验资料:ISRCTN11883920)已得出结论。主要研究已经证明,2至3年的他莫昔芬至依西美坦的辅助内分泌治疗与临床相关功效的改善有较大相关度,现在主要报道实验的最终疗效分析。

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