Am J Trop Med Hyg：变革性研究有望终止全球很大的传染病之一：肺结核

2018-03-11 Lily 译自Medicalxpress 来宝网

根据2018年3月发表在《美国热带医学与卫生杂志》上的一篇文章指出，为了控制并最终消灭结核病，必须采取更密集的生物医学研究方法。在这篇文章中，美国国立卫生研究院下属的国家过敏和传染病研究所(NIAID)所长讨论了通过应用新的诊断、治疗和疫苗方法实现结核病研究现代化的必要性。

根据2018年3月发表在《美国热带医学与卫生杂志》上的一篇文章指出，为了控制并最终消灭结核病，必须采取更密集的生物医学研究方法。在这篇文章中，美国国立卫生研究院下属的国家过敏和传染病研究所(NIAID)所长讨论了通过应用新的诊断、治疗和疫苗方法实现结核病研究现代化的必要性。

结核病是一种典型的肺部细菌感染，是人类已知的最古老的疾病之一，也是全世界主要的死亡传染病之一。作者回顾了自艾滋病首次被确认以来近37年来艾滋病毒研究取得的重大进展，并鼓励科学界努力实现类似的结核病里程碑。

具体来说，作者呼吁采用系统生物学方法(使用大数据集和建模来理解复杂的生物系统)，以填补了解结核分枝杆菌(Mtb)感染是如何引起疾病的关键知识空白。这样的研究可以帮助解释为什么一些感染mtb的人有潜在的感染而没有任何疾病的迹象，该观点还强调需要改进诊断测试，包括能够在各种标本中检测mtb的测试，以及快速、便宜的检测耐药结核病的测试。

漫长而复杂的治疗方案和越来越多的多重耐药结核病感染使这种疾病越来越难以治愈。作者们指出，最终的治疗目标应该是药物联合使用更短的时间来治疗感染任何一种Mtb病毒的人。另一个研究目标是安全和更广泛有效的疫苗，这仍然是最困难的挑战之一，然而，研究人员解释说，通过创新和积极的生物医学研究计划可迅速将结果转化为全球控制策略，疫苗和其他重大进展是可能的。

原始出处：Anthony S. Fauci, Robert W. Eisinger. Reimagining the Research Approach to Tuberculosis, The American Journal of Tropical Medicine and Hygiene (2018).

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2018-04-09 zwjnj2

学习学习认真学习永远学习

143 0
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2018-03-26 zwjnj2

好好好好学习天天向上好好

151 0
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2018-03-12 huhuaidong387

#结核#

98 0
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2018-03-12 ms3994565386320060

#Med#

111 0
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2018-03-12 三生有幸9135

学习一下谢谢分享

116 0
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2018-03-11 Ramsey

这个厉害了

106 0
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2018-03-11 1dd8c52fm63(暂无匿称)

学习学习.继续关注

121 0
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2018-03-11 ann y

变革性研究有望终止全球最大的传染病之一:肺结核

114 0
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2018-03-11 深海的鱼

学习学习学习学习

83 0
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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Sun Mar 11 06:57:10 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295080, encodeId=76d029508081, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Sun Mar 11 06:56:33 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295070, encodeId=cbed2950e0ee, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sun Mar 11 06:46:01 CST 2018, time=2018-03-11, status=1, ipAttribution=)]
2018-03-11 yjs木玉

好好好好好好好好

119 0