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N Z Med J:早期前列腺癌低剂量率近距离放射治疗10年结果的前瞻性预估

2018-11-18 AlexYang MedSci原创

诊断为早期阶段前列腺癌的新西兰男性需要知道他们的治疗选择将会产生怎样的预期结果。最近,有研究人员就诊断上述期望进行了相关研究。在2001年和2016年之间,951名新西兰男性接受了低剂量率近距离放射治疗(永久性碘125种子植入)。在治疗后跟踪调查期间,他们进行了PSA 检测和泌尿、排便和性副作用评分。研究发现,跟踪调查的平均时间为7.9年(2.0-16.3年)。10年PSA控制在551名低风险前列

诊断为早期阶段前列腺癌的新西兰男性需要知道他们的治疗选择将会产生怎样的预期结果。最近,有研究人员就诊断上述期望进行了相关研究。

在2001年和2016年之间,951名新西兰男性接受了低剂量率近距离放射治疗(永久性碘125种子植入)。在治疗后跟踪调查期间,他们进行了PSA 检测和泌尿、排便和性副作用评分。研究发现,跟踪调查的平均时间为7.9年(2.0-16.3年)。10年PSA控制在551名低风险前列腺癌患者中占比95%,在中等程度风险400名前列腺癌男性中占比82%。副作用时间一般情况下微小并且短暂。移植后暂时性尿路梗阻发生的比例为2.6%,并且10年累积的尿道狭窄风险为2.6%。勃起功能异常在29%的男性中发生,其中三分之二的男性具有对PDE5抑制剂良好的响应。大多数男性在移植后4天内回复正常。

最后,研究人员指出,LDR近距离放射治疗时新西兰早期前列腺癌有效的低副作用的治疗选择。

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  5. [GetPortalCommentsPageByObjectIdResponse(id=2085627, encodeId=c0ce208562ede, content=<a href='/topic/show?id=7cb79431441' target=_blank style='color:#2F92EE;'>#近距离放射治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94314, encryptionId=7cb79431441, topicName=近距离放射治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570c172, createdName=tigerlr98, createdTime=Sat Feb 09 23:54:00 CST 2019, time=2019-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006442, encodeId=b81d200644240, content=<a href='/topic/show?id=924a3264381' target=_blank style='color:#2F92EE;'>#前瞻性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32643, encryptionId=924a3264381, topicName=前瞻性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5cb32500112, createdName=1508842480_96220437, createdTime=Sun Jan 13 00:54:00 CST 2019, time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1813957, encodeId=33b1181395e12, content=<a href='/topic/show?id=e38794313f6' target=_blank style='color:#2F92EE;'>#近距离#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94313, encryptionId=e38794313f6, topicName=近距离)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Mon May 13 07:54:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953508, encodeId=d492195350829, content=<a href='/topic/show?id=b3ec60803a2' target=_blank style='color:#2F92EE;'>#期前列腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60803, encryptionId=b3ec60803a2, topicName=期前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Thu Dec 20 00:54:00 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480520, encodeId=6b92148052048, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Tue Nov 20 04:54:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609329, encodeId=3bb61609329db, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Nov 20 04:54:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353056, encodeId=de39353056d5, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Mon Nov 19 12:35:43 CST 2018, time=2018-11-19, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2085627, encodeId=c0ce208562ede, content=<a href='/topic/show?id=7cb79431441' target=_blank style='color:#2F92EE;'>#近距离放射治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94314, encryptionId=7cb79431441, topicName=近距离放射治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570c172, createdName=tigerlr98, createdTime=Sat Feb 09 23:54:00 CST 2019, time=2019-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006442, encodeId=b81d200644240, content=<a href='/topic/show?id=924a3264381' target=_blank style='color:#2F92EE;'>#前瞻性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32643, encryptionId=924a3264381, topicName=前瞻性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5cb32500112, createdName=1508842480_96220437, createdTime=Sun Jan 13 00:54:00 CST 2019, time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1813957, encodeId=33b1181395e12, content=<a href='/topic/show?id=e38794313f6' target=_blank style='color:#2F92EE;'>#近距离#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94313, encryptionId=e38794313f6, topicName=近距离)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Mon May 13 07:54:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953508, encodeId=d492195350829, content=<a href='/topic/show?id=b3ec60803a2' target=_blank style='color:#2F92EE;'>#期前列腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60803, encryptionId=b3ec60803a2, topicName=期前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Thu Dec 20 00:54:00 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480520, encodeId=6b92148052048, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Tue Nov 20 04:54:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609329, encodeId=3bb61609329db, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Nov 20 04:54:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353056, encodeId=de39353056d5, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Mon Nov 19 12:35:43 CST 2018, time=2018-11-19, status=1, ipAttribution=)]
    2018-11-20 hb2008ye
  7. [GetPortalCommentsPageByObjectIdResponse(id=2085627, encodeId=c0ce208562ede, content=<a href='/topic/show?id=7cb79431441' target=_blank style='color:#2F92EE;'>#近距离放射治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94314, encryptionId=7cb79431441, topicName=近距离放射治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570c172, createdName=tigerlr98, createdTime=Sat Feb 09 23:54:00 CST 2019, time=2019-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006442, encodeId=b81d200644240, content=<a href='/topic/show?id=924a3264381' target=_blank style='color:#2F92EE;'>#前瞻性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32643, encryptionId=924a3264381, topicName=前瞻性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5cb32500112, createdName=1508842480_96220437, createdTime=Sun Jan 13 00:54:00 CST 2019, time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1813957, encodeId=33b1181395e12, content=<a href='/topic/show?id=e38794313f6' target=_blank style='color:#2F92EE;'>#近距离#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94313, encryptionId=e38794313f6, topicName=近距离)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Mon May 13 07:54:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953508, encodeId=d492195350829, content=<a href='/topic/show?id=b3ec60803a2' target=_blank style='color:#2F92EE;'>#期前列腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60803, encryptionId=b3ec60803a2, topicName=期前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Thu Dec 20 00:54:00 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480520, encodeId=6b92148052048, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Tue Nov 20 04:54:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609329, encodeId=3bb61609329db, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Nov 20 04:54:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353056, encodeId=de39353056d5, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Mon Nov 19 12:35:43 CST 2018, time=2018-11-19, status=1, ipAttribution=)]
    2018-11-19 一个字-牛

    学习了谢谢分享

    0

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前列腺癌(PCa)患者的健康差异潜在的分子机制还没有很好的阐释。最近,有研究人员应用了生物信息学手段鉴定和确认了具有肿瘤恶化的非裔美国人(AA)中,与白种美国人(CA)相比表达失调的基因。研究人员总共分析了619名PCa患者的基因芯片数据,其中412名为AA,207名为CA。研究人员通过RT-PCR、蛋白免疫印迹、免疫细胞化学(ICC)和免疫组织化学分析在肿瘤组织和细胞系中确定了这些基因。研究人员

Oncogene:前列腺癌细胞与骨细胞通过膜泡RNA交流的研究

胞外囊泡(EVs)作为细胞之间交流的工具,在肿瘤和其微环境之间所起的作用研究较少,并且还是一个相对新的概念。科学的假设中指出,EVs在肿瘤产生远距离转移性微环境中具有重要作用,并且在前列腺癌中尤其如此,另外,在前列腺中,在骨组织中产生微环境尤其明显。EVs在PCa细胞和骨组织细胞,比如造骨细胞,之间的交流中所起的潜在作用还没有很好的阐释。最近,有研究人员阐释了PCa细胞EVs能够增强造骨细胞的生存

Cancer Sci:2''-羟基肉桂醛能够抑制细胞增殖和细胞凋亡

信号转换和激活转录3(STAT3)信号途径的抑制已经成为治疗人类癌症的新的治疗策略,具体是通过持续的活性STAT3的表达。通过对自然产物的筛选来发现STAT3抑制剂,研究人员鉴定了2'-羟基肉桂醛(HCA)可以作为STAT3的抑制剂,并可以从肉桂的树皮中分离得到。通过生物化学的方法,包括了pull-down试验和细胞热转移试验(CETSA),研究发现HCA可以直接与STAT3结合来选择性的抑制ST

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