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Biochemia Medica：维生素K缺乏症II (PIVKA-II)诱导蛋白作为胰腺癌潜在的血清学生物标志物:一项初步研究

2019-08-03 不详 MedSci原创

血清学生物标志物
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胃肠道恶性肿瘤患者中，维生素<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:"Calibri","sans-serif"; mso-fareast-font-family:宋体;mso-bidi-font-family:"Times

胃肠道恶性肿瘤患者中，维生素K缺乏症(PIVKA-II)诱导蛋白是一种异常的凝血酶原升高。本研究的目的是评价PIVKA-II与PC患者和胰腺良性疾病患者中已建立的胰腺癌(PC)生物标志物(ca19 -9、癌胚抗原(CEA)和ca242)的比较。

我们研究了26名PC患者（第1组）和20名良性胰腺疾病患者（第2组）。 通过化学发光酶免疫测定法（CLEIA）在LUMIPULSE G1200（Fujirebio-Europe，Gent，Belgium）上测量PIVKA-II和CEA，通过ELSA（CisBio Bioassays，Codolet，France）和EIA（EIA） Fujirebio Diagnostics AB，Göteborg，Sweden）测量CA 19-9和CA 242。。应用ROC分析评估两组生物标志物的诊断特征。

研究结果显示，第1组和第2组的PIVKA-II中位数和四分位数间距（IQR）分别为1749.0（320.2-3921.0）与31.0（23.0-43.0）mAU/mL（P <0.001），CA 19-9分别为260.0（158.7-272.0）与104.0（9.0-58.0）U/mL（P = 0.034）；CA 242分别为104.0（30.2-150.0）与7.2（4.8-26.0）U/mL（P <0.050；PIVKA-II分别为9.4（5.3-37.5）与4.5（1.8-7.0）ng/mL（P = 0.021）。PIVKA-II, CA 19-9, CA 242, CEA的ROC曲线下面积分别为0.86（95％CI：0.71-1.00），0.58（95％CI：0.38-0.78），0.73（95％CI：0.54-0.92），0.64（95％CI：0.44-0.85）。

研究表明，在PC中PIVKA-II明显高于胰腺良性疾病。与CA 19-9、CEA、CA242相比，PIVKA-II具有较好的诊断性能，对其检测有助于PC管理。

原始出处：

Sara Tartaglione ,Irene Pecorella,Protein Induced by Vitamin K Absence II (PIVKA-II) as a potential serological biomarker in pancreatic cancer: a pilot study

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    2020-07-04 jeanqiuqiu

    #DIC#

    0

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    2020-04-17 sunylz

    #Bio#

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    2019-12-20 hukaixun

    #标志物#

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likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89381, encryptionId=52f089381e5, topicName=血清学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43126964261, createdName=jjjiang0201, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560841, encodeId=4a0f1560841eb, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566850, encodeId=20ef1566850d7, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609909, encodeId=068c1609909a3, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=)]
    2020-01-23 zhwj

    #VKA#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1858980, encodeId=42a218589801f, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Sat Jul 04 21:07:00 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918802, encodeId=326b191880283, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, 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topicName=VKA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a4cc36527971, createdName=zhwj, createdTime=Thu Jan 23 16:07:00 CST 2020, time=2020-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425726, encodeId=6ca71425e26d9, content=<a href='/topic/show?id=8524e9083c6' target=_blank style='color:#2F92EE;'>#维生素K#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79083, encryptionId=8524e9083c6, topicName=维生素K)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca0d3990423, createdName=bsmagic9133, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468971, encodeId=c80d14689e1c7, content=<a href='/topic/show?id=52f089381e5' target=_blank style='color:#2F92EE;'>#血清学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89381, encryptionId=52f089381e5, topicName=血清学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43126964261, createdName=jjjiang0201, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560841, encodeId=4a0f1560841eb, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566850, encodeId=20ef1566850d7, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609909, encodeId=068c1609909a3, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=)]
    2019-08-05 bsmagic9133

    #维生素K#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1858980, encodeId=42a218589801f, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Sat Jul 04 21:07:00 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918802, encodeId=326b191880283, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, 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likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89381, encryptionId=52f089381e5, topicName=血清学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43126964261, createdName=jjjiang0201, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560841, encodeId=4a0f1560841eb, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566850, encodeId=20ef1566850d7, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609909, encodeId=068c1609909a3, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=)]
    2019-08-05 jjjiang0201

    #血清学#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1858980, encodeId=42a218589801f, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Sat Jul 04 21:07:00 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918802, encodeId=326b191880283, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, 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time=2019-08-05, status=1, ipAttribution=)]
    2019-08-05 zhu_jun9842

    #生物标志#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1858980, encodeId=42a218589801f, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Sat Jul 04 21:07:00 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918802, encodeId=326b191880283, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, 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topicName=VKA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a4cc36527971, createdName=zhwj, createdTime=Thu Jan 23 16:07:00 CST 2020, time=2020-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425726, encodeId=6ca71425e26d9, content=<a href='/topic/show?id=8524e9083c6' target=_blank style='color:#2F92EE;'>#维生素K#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79083, encryptionId=8524e9083c6, topicName=维生素K)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca0d3990423, createdName=bsmagic9133, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468971, encodeId=c80d14689e1c7, content=<a href='/topic/show?id=52f089381e5' target=_blank style='color:#2F92EE;'>#血清学#</a>, beContent=null, objectType=article, channel=null, level=null, 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href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609909, encodeId=068c1609909a3, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=)]
    2019-08-05 zhu_jun9842

    #生物标志#

    0

  9. 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createdName=sunylz, createdTime=Fri Apr 17 13:07:00 CST 2020, time=2020-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841417, encodeId=594d184141e3b, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Dec 20 08:07:00 CST 2019, time=2019-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1752390, encodeId=49081e52390c6, content=<a href='/topic/show?id=3e7a184847b' target=_blank style='color:#2F92EE;'>#VKA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18484, encryptionId=3e7a184847b, 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href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609909, encodeId=068c1609909a3, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Aug 05 14:07:00 CST 2019, time=2019-08-05, status=1, ipAttribution=)]
    2019-08-05 ms3994565386320060

    #Med#

    0

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