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BMC Med:褪黑素能让创伤性脑损伤脱离失眠苦海

2018-02-23 贾朝娟 环球医学

失眠,能把正常人都折磨的智商降低生无可恋,而创伤性脑损伤(TBI)患者的后果将更加严重。TBI患者只有睡的好,损伤的脑细胞才能恢复。所有营养神经的药物都不如优质睡眠有奇效。然而,TBI患者发生睡眠障碍的发生率非常高。

失眠,能把正常人都折磨的智商降低生无可恋,而创伤性脑损伤(TBI)患者的后果将更加严重。TBI患者只有睡的好,损伤的脑细胞才能恢复。所有营养神经的药物都不如优质睡眠有奇效。然而,TBI患者发生睡眠障碍的发生率非常高。

2018年1月,发表在《BMC Med》的一项研究调查了褪黑素补充治疗创伤性脑损伤(TBI)后睡眠障碍的有效性。

这是一项随机双盲安慰剂对照双阶段双治疗(褪黑素和安慰剂)交叉研究。

从澳大利亚墨尔本埃普沃思奥斯丁医院招募门诊患者。患者为轻度至重度TBI(33例),并在创伤后患有睡眠障碍(平均37岁,67%为男性)。患者接受长效释放褪黑激素制剂和安慰剂胶囊治疗各4周,并以48小时的洗脱期进行药物效应抵消。每晚临睡前2小时进行治疗。监测严重不良事件和副反应。

研究结果显示,相对于安慰剂,褪黑素补充可显著降低总体匹兹堡睡眠质量指数评分,这表明褪黑素可显著改善睡眠质量(P≤0.0001)。但褪黑素对睡眠潜伏期无影响。

在次要结局上,褪黑素补充可显著增加腕动计显示的睡眠效率和SF-36 v1调查问卷显示的活力与心理健康评分。褪黑素可明显降低医院焦虑抑郁量表测量的焦虑评分和疲劳严重程度量表测量的疲劳频分,但是对Epworth嗜睡量表评分测量的白天嗜睡无显著影响。

无严重不良事件发生。

作者认为,褪黑素补充4周对改善TBI患者主观睡眠质量以及一些方面的客观睡眠质量安全有效。

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    2018-07-12 amyloid
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