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Gastroenterology:症状性及质子泵抑制剂难治性胃食管反流病发病率研究

2020-04-20 MedSci原创 MedSci原创

通过人群调查,研究人员发现胃食管反流病症状十分常见:5名参与者中有2人在过去存在GERD症状,3人中有1人在过去一周有过GERD症状。研究人员还发现一半的PPI使用者有持续的症状。鉴于GERD对生活质

近日研究人员开展基于人群研究,考察使用质子泵抑制剂(PPI)后对胃食管反流病(GERD)症状和持续性症状的影响。
 
MyGiHealth研究始于2015年,为全国胃肠道调查。主要结果是服用PPIs的受试者GERD症状率和持续GERD症状(定义为一周内胃灼热或反流超过2天)。
 
在71812名参与者中,32878名(44.1%)报告过去存在GERD症状,23039名(30.9%)报告过去一周有过GERD症状。研究人员还发现,35.1%有GERD症状的患者目前正在接受治疗(55.2%使用PPIs,24.3%使用组胺-2受体阻滞剂,24.4%使用抗酸剂)。在每天服用PPIs的3229名参与者中,54.1%有持续性GERD症状。年轻人、女性、拉丁美洲人和患有肠易激综合征或克罗恩病的参与者更有可能出现持续症状,即使在服用PPIs时也是如此。
 
通过人群调查,研究人员发现胃食管反流病症状十分常见:5名参与者中有2人在过去存在GERD症状,3人中有1人在过去一周有过GERD症状。研究人员还发现一半的PPI使用者有持续的症状。鉴于GERD对生活质量的显著影响,PPI难治性GERD症状患者需要进一步研究和开发新的治疗方法。
 
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createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Jun 06 23:44:04 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823627, encodeId=6440182362e25, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Thu Jun 25 17:44:04 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065043, encodeId=749820650435b, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, 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createdName=jklm09, createdTime=Wed Apr 22 09:44:04 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437535, encodeId=fd75143e5356b, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Apr 22 09:44:04 CST 2020, time=2020-04-22, status=1, ipAttribution=)]
  5. 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createdName=jklm09, createdTime=Wed Apr 22 09:44:04 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437535, encodeId=fd75143e5356b, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Apr 22 09:44:04 CST 2020, time=2020-04-22, status=1, ipAttribution=)]
    2021-03-09 许安
  6. 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createdName=jklm09, createdTime=Wed Apr 22 09:44:04 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437535, encodeId=fd75143e5356b, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Apr 22 09:44:04 CST 2020, time=2020-04-22, status=1, ipAttribution=)]
    2020-06-29 jklm09
  7. 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    2020-04-22 zhouqu_8

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质子泵抑制剂(proton pump inhibitor,PPI)通过抑制胃壁细胞上的H+/K+-ATP酶,强而持久地抑制胃酸分泌,目前PPI广泛用于治疗胃食管反流病、消化性溃疡、幽门螺杆菌感染、上消化道出血、卓-艾综合征等酸相关性疾病。 目前PPI的不合理使用主要表现在预防性用药指征不明确和预防疗程过长。为此,广东省药学会组织药学及临床专家特制定本指导意见,为规范临床预防性使用PPI提供参考

BMJ:质子泵抑制剂和组胺受体拮抗剂对胃肠道出血的预防效果

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J Gastroenterology:长期使用质子泵抑制剂与胰腺癌的关系

目前,质子泵抑制剂(PPI)的长期安全性受到越来越多的质疑。本项研究的目的是评估长期PPI使用者中胰腺癌发生的风险。

质子泵抑制剂、免疫抑制剂……这些药吃对了吗?

免疫抑制剂疗法可能影响肿瘤的免疫控制,导致肿瘤发生、扩散和复发。近日,一项研究显示,免疫抑制剂疗法未增炎症性肠病(IBD)患者肿瘤风险。

JAMA:ICU中质子泵抑制剂预防应激性溃疡有效吗?

2020年2月来自新西兰的aul J.Young等在 JAMA 上公布了PEPTIC试验结果,目的在于验讫在 ICU 中使用质子泵抑制剂(PPI)和使用 H-2受体阻滞剂(H2RB)对在院死亡率的作用

JAMA Pediatr:警惕质子泵抑制剂导致儿童骨折风险

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