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Front Microbiol:研究人员在口腔癌前病变中发现重要的细菌!

2017-12-11 佚名 “细胞”微信号

三一学院牙科学院的科学家已经做出了一个重要的发现,涉及细菌和癌前期的生长,称为口腔白斑,可以先于口腔癌出现。

三一学院牙科学院的科学家已经做出了一个重要的发现,涉及细菌和癌前期的生长,称为口腔白斑,可以先于口腔癌出现。

研究人员检查了口腔白斑的微生物组,以确定某些细菌是否与口腔白斑相关,以及细菌的类型是否可以预测这些疾病是否变得恶性。他们的研究结果最近发表在国际同行评议的期刊Frontiers in Microbiology。

口腔癌是世界上第八大最常见的癌症。像所有癌症一样,癌症的早期诊断大大提高了生存的机会。有时,口腔癌先于癌前生长,鉴别这些可以改善长期生存。

其中一种癌症前期被称为口腔白斑,字面意思是“白斑”。尽管吸烟是口腔粘膜白斑的一个危险因素,但是我们仍然不明白口腔粘膜白斑是癌变还是恶变。

研究人员在研究这种前癌症时发现,与同一病人的健康部位相比,某些细菌在白色斑块中更多地被发现。这包括Fusobacteria(Fusobacterium物种和Leptotrichia物种)和Campylobacter物种。

最近的研究显示,结肠癌中梭状杆菌和弯曲杆菌的含量高,并且与结肠癌进展有关。

Trinity研究表明,类似的细菌可能参与口腔癌症的进展。研究显示恶性程度较高的白色斑块倾向于显示较高水平的梭状杆菌和弯曲杆菌属(Campylobacter spp)。

正在进行进一步的研究以追踪这些患者,并确定存在的细菌类型是否可以确定白斑是否癌变,以及局部抗生素疗法是否可用于预防恶性转化。

谈到这项研究的重要性,主要作者Gary Moran说:“我们的研究支持细菌可能参与胃肠道癌症发展的想法,并且抗菌疗法可以用来减缓其发展。”

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    2018-08-03 sunylz
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    2018-02-09 xjy02
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