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ACC:美学者称,心梗后心脏破裂不少见

2018-04-22 卢芳 中国循环杂志

“心梗后心脏破裂常常被归为罕见并发症,但实际上要比想象中更为常见。”近日有两位美国学者在ACC网站上发文说。

“心梗后心脏破裂常常被归为罕见并发症,但实际上要比想象中更为常见。”近日有两位美国学者在ACC网站上发文说。

他们表示,如果没有尸检或影像学证据,急性心梗时心原性猝死很容易被归咎为心肌死亡、顽固性心律失常、传导阻滞或者肺栓塞等各种原因,而心脏破裂常常被忘到“爪哇国”了。

有幸的是,将患者快速转运到导管室并使用影像学手段检查能有机会发现即将破裂的心脏。

心脏破裂到底有多常见?一项对41例女性和112例男性急性心梗猝死患者进行的回顾性研究发现,有47例(30.7%)患者发生心脏破裂,其中女性患者心脏破裂风险高于男性(60%vs 20%)。

心脏破裂部位,有21例发生在前壁(45%),18例为后壁(38%)、4例为侧壁(9%),3例为心尖部(6%),右心室最少为1例(2%)。

这47例患者尽管导管室检查表明有多支病变,但之前并未出现相对应的冠心病症状;其中35例患者之前无相关病史。

该研究提示,急性心梗住院前后早期猝死,心脏破裂占有较大比例。

此外,心室游离壁破裂似乎有所下降,有单中心纵向研究显示,总体发生率为4%,但进一步分层研究显示,心室游离壁破裂的发生率从1977-1982年>4%,下降到2001-2006年的<2%。死亡率也从94%下降到75%。

就心脏破裂时间,VALIANT研究中98例心原性猝死心梗患者,有40%由致命性心梗或心脏破裂所致。复发性心梗或心脏破裂多在急性心梗后早期发生,尤其在第一个月内多见,之后随时间推移而下降。

哪些心梗患者是心脏破裂高危人群?有研究显示,SYNTAX Score和SYNTAX Score II评分较高的STEMI患者,心肌破裂风险较高。

此外,还需要考虑的危险因素包括:首次心梗且无侧枝血流、前壁或外侧壁梗死、梗死面积、女性、大于70岁、持续性ST抬高、持续高血压、反复或持续性胸痛并伴有梗死扩展证据。

还有其他研究显示,如果患者年龄小或症状延迟,梗死面积小,或再灌注不成功,都有心脏破裂风险。

而患者接受PCI治疗,以及对心脏破裂患者行紧急手术,都可改善患者预后。

有心脏破裂倾向的患者,多在非特异性心电图改变情况下主诉胸痛,还可发展为心包填塞和/或休克,最终导致心脏骤停。

影像学检查有助于明确诊断,心导管插入过程中行左心室造影有助于明确心脏破裂(图1);此外标准经胸超声心动图偶然也可见心脏血肿(图2);CT扫描可很直观观察到破裂部位。



图1 左心室造影可见对比剂渗入心肌



图2 伴有中度心包积液的右心室塌陷和心包内血肿



图3 对比剂渗透可见左心室侧壁缺损

有研究利用心脏磁共振成像对比有心脏破裂倾向或有心包积液的患者和其它患者发现,即将发生心脏破裂患者症状延迟,其下壁或下侧壁出现透壁坏死也更为多见。此外,发生内壁血肿或血栓以及微血管梗阻的风险也增加。

总之,尽快发现并施治对心脏破裂患者生存很关键,经胸超声心动图或对及时判断有所助益。正性肌力药、血管加压药物以及稳定血流动力学的液体疗法等都可在初始治疗派上用场。此外一些机械装置,如ECMO、IABP以及其他装置,都有助于稳定血流动力学,直至行外科手术。

原始出处:
RhianE Davies, Ian C.Gilchrist. Contemporary Management of Post-MI Myocardial Rupture. ACC. Apr 16,2018.

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    2019-02-17 lfyang
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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Apr 22 13:05:38 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-25 执着追梦

    学习.谢谢分享

    0

  4. 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  5. 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  6. 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level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Apr 23 00:46:47 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308268, encodeId=b17c308268c5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun Apr 22 15:23:24 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308235, encodeId=a23e30823586, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2018-04-23 易水河

    学习学习了

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Mon Apr 23 12:06:51 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308396, encodeId=6a4f308396b0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq08fBE4ne4yAYXulsHUXiafWXWEQ1kDkMHtT9loagc1nibPCrwjpESVuPO4De8QTeajAic31lDPfjuA/132, createdBy=92ce1931739, createdName=荒郊野树, createdTime=Mon Apr 23 06:45:41 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308352, encodeId=d54f30835254, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Apr 23 00:46:47 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308268, encodeId=b17c308268c5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun Apr 22 15:23:24 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308235, encodeId=a23e30823586, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Apr 22 13:05:38 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-23 荒郊野树

    学习

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Mon Apr 23 12:06:51 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308396, encodeId=6a4f308396b0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq08fBE4ne4yAYXulsHUXiafWXWEQ1kDkMHtT9loagc1nibPCrwjpESVuPO4De8QTeajAic31lDPfjuA/132, createdBy=92ce1931739, createdName=荒郊野树, createdTime=Mon Apr 23 06:45:41 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308352, encodeId=d54f30835254, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Apr 23 00:46:47 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308268, encodeId=b17c308268c5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun Apr 22 15:23:24 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308235, encodeId=a23e30823586, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Apr 22 13:05:38 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-23 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  9. 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attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Mon Apr 23 12:06:51 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308396, encodeId=6a4f308396b0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq08fBE4ne4yAYXulsHUXiafWXWEQ1kDkMHtT9loagc1nibPCrwjpESVuPO4De8QTeajAic31lDPfjuA/132, createdBy=92ce1931739, createdName=荒郊野树, createdTime=Mon Apr 23 06:45:41 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308352, encodeId=d54f30835254, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Apr 23 00:46:47 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308268, encodeId=b17c308268c5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun Apr 22 15:23:24 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308235, encodeId=a23e30823586, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Apr 22 13:05:38 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-22 yfjms

    学习

    0

  10. 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level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Apr 23 00:46:47 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308268, encodeId=b17c308268c5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun Apr 22 15:23:24 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308235, encodeId=a23e30823586, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Apr 22 13:05:38 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-22 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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病例分享:心梗之外的无声杀手 ——从1例跌宕起伏的急性胸痛病例说开去

急性胸痛是急诊内科最常见的疾病。调查发现,急性胸痛在门诊接诊的患者中占20%,在救护车接诊的患者中占69%,在急诊室接诊的患者中占45%。对于急性胸痛首先应明确是否由潜在致死性疾病引起,如急性心肌梗死(AMI)、主动脉夹层(AD)、急性肺栓塞和张力性气胸等,需要在短时间内作出恰当诊断和处理。若误诊或漏诊,会导致严重后果。

阜外研究:≥80岁心梗患者脑卒中发生率高

高危、高龄,一直是让人关注的患者群体。那些行直接经皮冠脉介入治疗(PPCI),并需主动脉内球囊反搏(IABP)辅助支持的≥80岁的急性心肌梗死患者临床转归如何?

病例分享:心梗可不止会胸闷痛,这种情况你想到没?

73岁男性,反复头痛6个月,劳累或受凉后诱发,休息后头痛通常会迅速缓解。6周前头痛再发加重,频率增加,较低水平活动可发生。同时运动中出现轻微胸痛,然而头痛更明显。既往有2型糖尿病病史10年,无周围神经病变或视网膜病变,仅有轻度肾损害(eGFR 50 mL/min/1.73 m2)。有创伤性硬膜下出血手术史6年,术后2年经磁共振明确诊断为脑梗死。

缺少心肌损伤标志物 “心梗”患者其实是外伤所致

男,45岁,汉族。持续性胸痛1小时。

凌晨西安6人先后心梗急救 近期气温骤降是诱因

停暖后西安气温骤降,剧烈的天气变化给慢性病患者带来风险。3月20日凌晨,先后有6名患者因为急性心肌梗死到西安医学院第一附属医院就医,医院紧急开通绿色通道进行抢救,幸好手术成功患者们转危为安。停暖后西安气温骤降,剧烈的天气变化给慢性病患者带来风险。3月20日凌晨,先后有6名患者因为急性心肌梗死到西安医学院第一附属医院就医,医院紧急开通绿色通道进行抢救,幸好手术成功患者们转危为安。“没想到凌晨来了这么

JAHA:TCT大会期间,美国心梗患者死亡率较低,尤其是NSTEMI

近日哈佛医学院学者在美国心脏协会杂志(JAHA)刊登的一项研究表明,在美国经导管心血管治疗学术会议(TCT)期间,住院的急性心肌梗死患者30天死亡率较低,尤其是非ST段抬高型心梗(NSTEMI)死亡率有差别。

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