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PLoS One:缺血性卒中患者,右颈动脉狭窄和认知功能相关

2016-01-26 phylis 译 MedSci原创

探讨急性缺血性脑卒中患者颈动脉狭窄与认知功能障碍的关系,并提供重要的临床意义。研究者测量了3116名急性缺血性脑卒中患者,颈动脉狭窄程度并记录简易精神状态检查评分(MMSE)。应用多变量回归分析,颈动脉狭窄与认知功能障碍(MMSE评估)的关联。也对其他感兴趣的临床变量进行了研究。在校正了年龄、性别、教育程度、婚姻、饮酒、吸烟、体力活动、高血压、糖尿病、高胆固醇血症、心房纤颤、心肌梗死、NIHSS(

探讨急性缺血性脑卒中患者颈动脉狭窄与认知功能障碍的关系,并提供重要的临床意义。

研究者测量了3116名急性缺血性脑卒中患者,颈动脉狭窄程度并记录简易精神状态检查评分(MMSE)。应用多变量回归分析,颈动脉狭窄与认知功能障碍(MMSE评估)的关联。也对其他感兴趣的临床变量进行了研究。


在校正了年龄、性别、教育程度、婚姻、饮酒、吸烟、体力活动、高血压、糖尿病、高胆固醇血症、心房纤颤、心肌梗死、NIHSS(美国国立卫生院卒中量表)评分后,研究者发现:与那些无颈动脉狭窄的患者相比,颈动脉重度狭窄者的患者认知障碍较严重(OR 1.49,95% CI:1.05-2.11)。左颈总动脉狭窄与认知障碍,在单因素分析中相关,但在校正NIHSS评分后,这种影响不存在。

认知功能障碍与右颈动脉重度狭窄相关。

原文出处:


Yue W, Wang A,et al. Association between Carotid Artery Stenosis and Cognitive Impairment in Stroke Patients: A Cross-Sectional Study. PLoS One. 2016 Jan 11

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目的:研究与欧洲规定的,严重卒中患者(NIHSS 15-25)静脉溶栓相比,非常严重的卒中患者( NIHSS > 25)静脉溶栓的安全性。方法:2002-2013年间SITS国际卒中溶栓登记的793家医院中,接受IV组织型纤溶酶原激活剂的急性缺血性卒中患者57247名。868名患者(1.5%)NIHSS评分> 25,19995(34.9%)有NIHSS评分15-25。预后为:脑实质出血

Cerebrovasc Dis:缺血性卒中后可早期进行降压治疗吗?

背景:越来越多的证据表明,高血压(BP)脑水肿的发生和缺血性卒中出血转化的风险,在急性缺血性卒中(AIS),低血压与不良预后相关。AIS后,最好的处理高血压的方法仍然是不确定的。材料与方法:搜索英文数据库,1990年1月到2015年8月,识别IS后早期降压(症状开始后48小时)对预后的影响的相关随机对照试验。研究者制定严格的纳入标准,应用Review Manager 5.2软件计算组合的风险比(R

PLoS One:涉及岛叶皮质的缺血性卒中,可能是心源性栓塞的危险因素

目的:评估心源性脑栓塞是否与岛叶部位缺血性脑卒中相关。方法:识别症状开始7天内的住院的缺血性卒中患者。基于弥散加权成像,研究包括大脑中动脉(MCA)中缺血性病变。根据梗死是否涉及岛叶,将患者分为两组中一组。主要预后为根据是否涉及岛叶,比较心源性脑栓塞的频率。共有MCAO供血区发生缺血性卒中的患者,112名(8.5%)涉及到岛叶。与未涉及岛叶(30.4%)的患者相比,涉及岛叶卒中(52.7%)的患者

Am J Hypertens:缺血性卒中患者血压变异率和住院死亡率不相关

背景:最近的数据表明,血压(BP)的变异率可独立于血压增加心血管疾病的风险。研究者旨在评估缺血性卒中患者血压变异率和入院预后的相关性。方法:研究者前瞻性研究608例急性缺血性中风患者(39.5%为男性,年龄:79.1±6.6岁)。应用SD评估BP的变异率及入院收缩压(SBP)和舒张压(DBP)的变异系数。出院的依赖率和住院死亡率评估预后。结果:不同的BP变异率间,患者的出院躯体状态没有差异。出院的

Neurology:偏头痛可增加急性缺血性卒中患者的梗死体积

目的:偏头痛,特别是有先兆的偏头痛,是缺血性中风的危险因素。最近研究:与野生型小鼠相比,突变偏头痛小鼠,因偏头痛大脑过度兴奋增加缺血边缘带到梗死区,进而增加梗死的体积。研究者推测,急性卒中时,有偏头痛病史的患者梗死体积增加。方法:在这个回顾性病例对照研究中,研究者识别偏头痛史的参与者,在症状开始72h内,应用弥散加权和灌注加权MRI测量病灶体积,计算灌注加权成像(PWI)和弥散加权成像(DWI高信

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