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JACC:可预测先天性心脏病成人患者心脏手术围手术期死亡风险的评分模型

2021-07-21 Nebula MedSci原创

PEACH评分是一种简单的、新的围手术期风险评分模型,可预测先天性心脏病成人患者进行心脏手术时的围手术期死亡风险

在先天性心脏病(ACHD)成人患者的心脏手术后,院内死亡是一种罕见、但令人恐惧的并发症。

Andrew等研究人员开展了一项研究,评估了EuroSCORE II指标和与手术相关的成人先天性心脏病手术(ACHS)评分的性能,同时确定了其他危险因素,并开发了一种新的风险评分,可用于预测ACHD手术后的住院死亡率。

研究人员先评估了2003年至2019年在一家大型三级医疗中心接受先天性心脏手术的16岁以上的患者的围手术期生存率,计算了每位患者的风险变量衍生的PEACH (围手术期ACHd)评分。并对该模型进行了内部和外部验证,还在另一个欧洲ACHD中心的患者验证队列中进行了测试。

PEACH评分分层患者的院内死亡率

开发队列纳入了1782台在研究期间进行的手术,其中897例(50.3%)再次进行了胸骨切开。共发生了31例(1.7%)院内死亡。PEACH评分表现出了优秀的鉴别能力(曲线下面积[AUC] 0.88;95%CI 0.83-0.94),优于ACHS评分(ACHS AUC:0.69; 95%CI 0.6-0.78; p=0.0003)。该模型划分了三个简单的风险分层:PEACH评分 0分(院内死亡率 0.2%)、1-2分(3.6%)和≥3分(17.2%)。

PEACH评分的预测表现

在包含975台手术的验证队列中,PEACH评分保持了其鉴别能力(AUC 0.75;95%CI 0.72-0.77),得到了良好的验证(p=0.55)。两组患者的预期死亡率和观察到的死亡率一致。

总而言之,PEACH评分是一种专门用于进行心脏手术的ACHD患者的简单的、新的围手术期风险评分模型。

原始出处:

Constantine Andrew,Costola Giulia,Bianchi Paolo et al. Enhanced Assessment of Perioperative Mortality Risk in Adults With Congenital Heart Disease.[J] .J Am Coll Cardiol, 2021, 78: 234-242. https://doi.org/10.1016/j.jacc.2021.04.096

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    2021-10-18 hbwxf
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    2021-07-23 huirong
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    2021-07-21 CHANGE

    梅斯里提供了很多疾病的模型计算公式,赞一个!

    0

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    2021-07-21 P.E.N.G

    学习

    0

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J Cardiothor Vas An:小儿心脏手术中脑电图监测下体外循环并深低温停循环的应用:一项系统回顾及Meta分析

心脏手术修复先天性心脏病对小儿发育中的大脑造成特定损伤。体外循环并深低温停循环(DHCA)是先天性心脏病修补术中一种简单有效的减少手术视野出血方法。然而,也有人担心,长时间的DHCA会增加神经系统损伤

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