Int J Epidemiol：摄入高水平的支链氨基酸也会增加糖尿病风险？

2016-09-27 Moon 译 MedSci原创

近期有研究显示，血浆支链氨基酸（BCAAs，包括亮氨酸、异亮氨酸和缬氨酸）与2型糖尿病的风险相关。膳食摄入是支链氨基酸的唯一来源；习惯性饮食摄入BCAAs对2型糖尿病又会有什么影响呢？我们对来自三项前瞻性队列（护士健康研究（NHS；从1980到2012年）；NHS II（从1991到2011年）；卫生专业人员随访研究（HPFS；从1986到2010年））的参与者进行了研究，评估BCAAs的

近期有研究显示，血浆支链氨基酸（BCAAs，包括亮氨酸、异亮氨酸和缬氨酸）与2型糖尿病的风险相关。膳食摄入是支链氨基酸的唯一来源；习惯性饮食摄入BCAAs对2型糖尿病又会有什么影响呢？

我们对来自三项前瞻性队列（护士健康研究（NHS；从1980到2012年）；NHS II（从1991到2011年）；卫生专业人员随访研究（HPFS；从1986到2010年））的参与者进行了研究，评估BCAAs的累积摄入量与2型糖尿病风险之间的联系。

在长达32年的随访中，共发生了16 097例2型糖尿病，校正人口相关和传统危险因素后，更高的总BCAA摄入量与更高的2型糖尿病风险有关。对所有队列进行荟萃分析，摄入量最低五分之一组与最高五分之一组相比，糖尿病风险的HR值分别为：亮氨酸 1.13 (1.07-1.19）；异亮氨酸 1.13 (1.07-1.19)；缬氨酸 1.11 (1.05-1.17)（所有P-trend < 0.001）。

对健康人群进行分析显示，更高的饮食中BCAAs含量与更高的血浆氨基酸水平显著相关（P-trend = 0.001）。

我们的数据表明，膳食摄入更多的支链氨基酸，与2型糖尿病风险的增加有关。

原始出处：

Yan Zheng,et al.Cumulative consumption of branched-chain amino acids and incidence of type 2 diabetes Int. J. Epidemiol. first published online July 13, 2016

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#插入话题

插入图片

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2016-10-15 一叶知秋

#氨基酸#

93 0
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2016-10-11 1e0d99ddm02(暂无匿称)

总结的很好！

95 0
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2016-10-11 1e0d99ddm02(暂无匿称)

总结的很好！

145 0
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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9a3e1625700, createdName=18719ba4d5m, createdTime=Wed Sep 28 00:28:01 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136570, encodeId=25161365e060, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:03:49 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136569, encodeId=4b0a136569a1, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:03:43 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
2016-10-11 1e0d99ddm02(暂无匿称)

分享一下！

113 0
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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9a3e1625700, createdName=18719ba4d5m, createdTime=Wed Sep 28 00:28:01 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136570, encodeId=25161365e060, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:03:49 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136569, encodeId=4b0a136569a1, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:03:43 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
2016-10-01 doctorJiangchao

继续关注

97 0
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authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:03:43 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
2016-10-01 doctorJiangchao

继续学习

97 0
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authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:03:43 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
2016-09-29 gongliu

#支链氨基酸#

68 0
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time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=144751, encodeId=8403144e5127, content=总结的很好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Oct 11 17:06:28 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=144750, encodeId=5a3c144e5007, content=分享一下！, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Oct 11 17:06:22 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138611, encodeId=7e4913861117, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Oct 01 15:03:13 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138610, encodeId=b29d138610d3, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Oct 01 15:03:07 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360743, encodeId=30871360e437c, content=<a href='/topic/show?id=c6335e17934' target=_blank style='color:#2F92EE;'>#支链氨基酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57179, encryptionId=c6335e17934, topicName=支链氨基酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Thu Sep 29 09:45:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136769, encodeId=2afc136e6908, content=学习啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9a3e1625700, createdName=18719ba4d5m, createdTime=Wed Sep 28 00:28:01 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136570, encodeId=25161365e060, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:03:49 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136569, encodeId=4b0a136569a1, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:03:43 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
2016-09-28 18719ba4d5m

学习啦

59 0
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time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=144751, encodeId=8403144e5127, content=总结的很好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Oct 11 17:06:28 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=144750, encodeId=5a3c144e5007, content=分享一下！, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Oct 11 17:06:22 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138611, encodeId=7e4913861117, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Oct 01 15:03:13 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138610, encodeId=b29d138610d3, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Oct 01 15:03:07 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360743, encodeId=30871360e437c, content=<a href='/topic/show?id=c6335e17934' target=_blank style='color:#2F92EE;'>#支链氨基酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57179, encryptionId=c6335e17934, topicName=支链氨基酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Thu Sep 29 09:45:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136769, encodeId=2afc136e6908, content=学习啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9a3e1625700, createdName=18719ba4d5m, createdTime=Wed Sep 28 00:28:01 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136570, encodeId=25161365e060, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:03:49 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136569, encodeId=4b0a136569a1, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:03:43 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
2016-09-27 知难而进

继续关注！

63 0
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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Oct 01 15:03:07 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360743, encodeId=30871360e437c, content=<a href='/topic/show?id=c6335e17934' target=_blank style='color:#2F92EE;'>#支链氨基酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57179, encryptionId=c6335e17934, topicName=支链氨基酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Thu Sep 29 09:45:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136769, encodeId=2afc136e6908, content=学习啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, 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authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:03:43 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
2016-09-27 知难而进

谢谢分享！

58 0

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