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Hypertension:低维生素D和维生素K水平与血压和高血压的相关性分析!

2017-04-12 xing.T MedSci原创

由此可见,低维生素D和维生素K水平与血压升高相关,并且与发生高血压风险增加的趋势有关。

维生素D和维生素K状态均与血管风险增加相关。从骨骼健康的实验研究的新证据表明维生素D和维生素K之间存在相互作用,但是,它们联合后与血管健康结局之间的相关性在很大程度上是未知的。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在前瞻性地在402例参与者中评估了低维生素D和维生素K水平是否与较高的收缩压和舒张压相关,以及在231例无基础高血压患者中评估低维生素D和维生素K水平与高血压发生之间的相关性。

研究人员使用的数据来自一个阿姆斯特丹老龄化纵向研究的子样本,该样本是由荷兰55-65岁的参与者组成的以人群为基础的队列。维生素D和维生素K的水平是通过检测在2002年至2003年期间保存的样品中25羟维生素D和dp-ucMDP(磷酸羧酸化基质Gla蛋白)浓度(dp-ucMDP水平高表明维生素K水平较低)来进行了评估。维生素D和维生素K的水平分为25羟维生素D<50/≥50mmol/L,平均dp-ucMDP<323/≥323pmol/L。

在平均6.4年的随访中,62%的参与者(n=143)发生高血压。维生素D和维生素K水平较低的患者与收缩压增加4.8mmHg(95%可信区间为0.1-9.5)和舒张压增加3.1mmHg(95%可信区间为0.5-5.7)相关,相比于高水平维生素D和维生素K的患者(收缩压交互作用P=0.013,舒张压交互作用P=0.068)。在高血压发生上也有类似的趋势:低水平维生素D和维生素K受试者发生高血压的风险比=1.62(95%可信区间为0.96-2.73)。

由此可见,低维生素D和维生素K水平与血压升高相关,并且与发生高血压风险增加的趋势有关。

原始出处:

Adriana J. van Ballegooijen, et al. Joint Association of Low Vitamin D and Vitamin K Status With Blood Pressure and Hypertension.Hypertension. 2017. https://doi.org/10.1161/HYPERTENSIONAHA.116.08869

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    2017-06-19 feather89
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createdName=ylzr123, createdTime=Fri Apr 14 07:47:20 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425696, encodeId=bcc414256969d, content=<a href='/topic/show?id=8524e9083c6' target=_blank style='color:#2F92EE;'>#维生素K#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79083, encryptionId=8524e9083c6, topicName=维生素K)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca0d3990423, createdName=bsmagic9133, createdTime=Fri Apr 14 03:44:00 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501150, encodeId=8305150115010, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Fri Apr 14 03:44:00 CST 2017, time=2017-04-14, status=1, ipAttribution=)]
    2017-05-14 177****8323

    学习

    0

  5. 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createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Apr 18 17:24:58 CST 2017, time=2017-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188247, encodeId=709218824e25, content=方法干活哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Mon Apr 17 14:29:06 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187267, encodeId=f0a718e26757, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Apr 14 07:47:20 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425696, encodeId=bcc414256969d, content=<a href='/topic/show?id=8524e9083c6' target=_blank style='color:#2F92EE;'>#维生素K#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79083, encryptionId=8524e9083c6, topicName=维生素K)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca0d3990423, createdName=bsmagic9133, createdTime=Fri Apr 14 03:44:00 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501150, encodeId=8305150115010, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Fri Apr 14 03:44:00 CST 2017, time=2017-04-14, status=1, ipAttribution=)]
    2017-04-25 为你把脉

    吃饭刚刚古古怪怪个

    0

  6. 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createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Apr 18 17:24:58 CST 2017, time=2017-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188247, encodeId=709218824e25, content=方法干活哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Mon Apr 17 14:29:06 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187267, encodeId=f0a718e26757, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Apr 14 07:47:20 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425696, encodeId=bcc414256969d, content=<a href='/topic/show?id=8524e9083c6' target=_blank style='color:#2F92EE;'>#维生素K#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79083, encryptionId=8524e9083c6, topicName=维生素K)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca0d3990423, createdName=bsmagic9133, createdTime=Fri Apr 14 03:44:00 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501150, encodeId=8305150115010, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Fri Apr 14 03:44:00 CST 2017, time=2017-04-14, status=1, ipAttribution=)]
    2017-04-18 为你把脉

    发图刚刚越远越好

    0

  7. 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createdName=ylzr123, createdTime=Fri Apr 14 07:47:20 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425696, encodeId=bcc414256969d, content=<a href='/topic/show?id=8524e9083c6' target=_blank style='color:#2F92EE;'>#维生素K#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79083, encryptionId=8524e9083c6, topicName=维生素K)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca0d3990423, createdName=bsmagic9133, createdTime=Fri Apr 14 03:44:00 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501150, encodeId=8305150115010, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Fri Apr 14 03:44:00 CST 2017, time=2017-04-14, status=1, ipAttribution=)]
    2017-04-17 为你把脉

    方法干活哈哈哈哈

    0

  8. 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createdName=shenxlcyp, createdTime=Sun Jan 21 06:44:00 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038626, encodeId=95d32038626bb, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Mon May 15 00:44:00 CST 2017, time=2017-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197928, encodeId=011419e928bb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Apr 18 17:24:58 CST 2017, time=2017-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188247, encodeId=709218824e25, content=方法干活哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Mon Apr 17 14:29:06 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187267, encodeId=f0a718e26757, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Apr 14 07:47:20 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425696, encodeId=bcc414256969d, content=<a href='/topic/show?id=8524e9083c6' target=_blank style='color:#2F92EE;'>#维生素K#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79083, encryptionId=8524e9083c6, topicName=维生素K)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca0d3990423, createdName=bsmagic9133, createdTime=Fri Apr 14 03:44:00 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501150, encodeId=8305150115010, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Fri Apr 14 03:44:00 CST 2017, time=2017-04-14, status=1, ipAttribution=)]
    2017-04-14 ylzr123

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。

    0

  9. 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createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Apr 18 17:24:58 CST 2017, time=2017-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188247, encodeId=709218824e25, content=方法干活哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Mon Apr 17 14:29:06 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187267, encodeId=f0a718e26757, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, 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encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Fri Apr 14 03:44:00 CST 2017, time=2017-04-14, status=1, ipAttribution=)]
  10. 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