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吸食大麻可致基因突变,甚至可遗传后代导致严重疾病

2016-05-26 MedSci MedSci原创

来自西澳大学的一项新的研究表明,吸食大麻会改变DNA,导致基因突变,从而可增加机体及其后代发生严重疾病的风险,其研究成果已在线发表于Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis。大麻是美国最常用的违禁药物,尽管其医疗或娱乐性使用合法化的地区正逐渐增加。据国家药物滥用研究所(NIDA)的数据显示,在过去的一

来自西澳大学的一项新的研究表明,吸食大麻会改变DNA,导致基因突变,从而可增加机体及其后代发生严重疾病的风险,其研究成果已在线发表于Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis。

大麻是美国最常用的违禁药物,尽管其医疗或娱乐性使用合法化的地区正逐渐增加。

据国家药物滥用研究所(NIDA)的数据显示,在过去的一个月里美国有2220万人使用大麻,且已有研究表明,近几年大麻的使用量明显增加。

鉴于大麻的大量使用,了解其对健康的影响则是非常重要的。

研究人员Albert Stuart Reece 和 Gary Hulse,均来自西澳大学精神病学与临床科学学院,指出既往研究已经表明大麻的使用与严重疾病发生风险的增加之间具有关联。

但是具体的关联机制目前尚未清楚。且研究人员洞悉了一些大麻使用是如何影响后代的。

大麻相关的基因损伤可遗传给后代

为了进一步探究,该研究小组对既往研究和文献资料进行了深入分析,以了解大麻对细胞的影响,以及与疾病发生风险之间的可能关联。

结果发现,大麻的化学成分(包括大麻的活性成份,四氢大麻酚(THC))也与机体的DNA反应并可改变机体的DNA,从而导致基因突变,增加疾病的发生风险。

他们指出,即使是吸食大麻者没有因这种DNA突变而发生疾病,但是这种“看不见”的伤害可遗传至下一代,甚至是再下一代后代,增加他们疾病的发生风险。

“即使母亲一生从未使用过大麻,而吸食大麻的父亲的精子也会导致其后代发生严重和致命的疾病,”Albert Stuart Reece说道,“父母可能没有意识到他们携带着这些或可处于休眠期的突变DNA,此突变或仅会影响其后代的健康,这才是最令人担忧的地方。”

Reece解释道,大麻的化学物质改变人的DNA,这可以减缓细胞的生长。这可能严重影响胎儿的生长发育,导致器官或四肢发育不成熟,还可诱导儿童癌症的发生。

最后,作者得出结论,他们的研究结果或对研究人员、医疗保健专业人士和决策者具有重要的意义,并应关注那些最易受大麻不良健康影响的个体。

原始出处:

Honor Whiteman. Cannabis use alters DNA to increase disease risk, study says. MNT, Wednesday 25 May 2016.


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  1. [GetPortalCommentsPageByObjectIdResponse(id=1665215, encodeId=93461665215ba, content=<a href='/topic/show?id=98af21196a0' target=_blank style='color:#2F92EE;'>#严重疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21196, encryptionId=98af21196a0, topicName=严重疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=002c25920844, createdName=ms6279672939590805, createdTime=Wed Jun 29 05:42:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140943, encodeId=a91e14094311, content=文章真心很好,感谢作者, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Oct 06 13:48:47 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92597, encodeId=62999259ee1, content=远离毒品,珍惜生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Jul 10 18:51:00 CST 2016, time=2016-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1933249, encodeId=cadb1933249a7, content=<a href='/topic/show?id=1bdd3945300' target=_blank style='color:#2F92EE;'>#吸食大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39453, encryptionId=1bdd3945300, topicName=吸食大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=af68384, createdName=hanhaisha2008, createdTime=Fri Nov 18 22:42:00 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87702, encodeId=b2988e702ce, content=不能收毒, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue May 31 05:42:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272656, encodeId=4c4212e2656a7, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sat May 28 10:42:00 CST 2016, time=2016-05-28, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1665215, encodeId=93461665215ba, content=<a href='/topic/show?id=98af21196a0' target=_blank style='color:#2F92EE;'>#严重疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21196, encryptionId=98af21196a0, topicName=严重疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=002c25920844, createdName=ms6279672939590805, createdTime=Wed Jun 29 05:42:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140943, encodeId=a91e14094311, content=文章真心很好,感谢作者, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Oct 06 13:48:47 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92597, encodeId=62999259ee1, content=远离毒品,珍惜生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Jul 10 18:51:00 CST 2016, time=2016-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1933249, encodeId=cadb1933249a7, content=<a href='/topic/show?id=1bdd3945300' target=_blank style='color:#2F92EE;'>#吸食大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39453, encryptionId=1bdd3945300, topicName=吸食大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=af68384, createdName=hanhaisha2008, createdTime=Fri Nov 18 22:42:00 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87702, encodeId=b2988e702ce, content=不能收毒, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue May 31 05:42:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272656, encodeId=4c4212e2656a7, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sat May 28 10:42:00 CST 2016, time=2016-05-28, status=1, ipAttribution=)]
    2016-10-06 1e10c84am36(暂无匿称)

    文章真心很好,感谢作者

    0

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    2016-07-10 oo902

    远离毒品,珍惜生命

    0

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    2016-05-31 忠诚向上

    不能收毒

    0

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    2016-05-28 kcb069

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