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JACC:CABG可显著降低非糖尿病多支冠状动脉疾病患者的死亡率

2016-06-29 phylis 译 MedSci原创

在多支冠状动脉疾病(CAD)糖尿病患者中,冠状动脉旁路移植术(CABG)和经皮冠状动脉介入治疗(PCI)相比,患者接受CABG后的生存受益多一些。不过,在非糖尿病患者中2种方法之间的死亡率差异数据很少。研究人员进行了一项患者水平的荟萃分析,比较了1275例非糖尿病多支CAD患者接受CABG vs 药物洗脱支架的PCI对长期死亡率的影响。研究人员汇集了SYNTAX 和BEST研究的个体患者数据。主要

在多支冠状动脉疾病(CAD)糖尿病患者中,冠状动脉旁路移植术(CABG)和经皮冠状动脉介入治疗(PCI)相比,患者接受CABG后的生存受益多一些。不过,在非糖尿病患者中2种方法之间的死亡率差异数据很少。

研究人员进行了一项患者水平的荟萃分析,比较了1275例非糖尿病多支CAD患者接受CABG vs 药物洗脱支架的PCI对长期死亡率的影响。

研究人员汇集了SYNTAX 和BEST研究的个体患者数据。主要结果是任何原因引起的死亡。

中位随访时间为61个月(四分范围:50个月〜62个月)。CABG组比PCI组的任何原因引起的死亡风险显著降低(危险比[HR]:0.65; 95%可信区间(CI):0.43至0.98; P=0.039)。心脏原因的引起的死亡风险也有类似的发现。对于主要临床亚组,CABG优于PCI是一致的。同样,CABG后心肌梗死率较PCI后明显降低(HR:0.40; 95%CI:0.24至0.65; P<0.001)。但是,2组的卒中率没有差异(HR:1.13; 95%CI:0.59至2.17; P=0.714)。CABG组需要再次血运重建概率比PCI组显著降低(HR:0.55; 95%CI:0.40至0.75; P<0.001)。

与药物洗脱支架PCI相比,CABG显著减少了非糖尿病多支冠脉病变的患者死亡率的长期风险。

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    2017-02-15 hbwxf
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    2016-07-03 午夜星河

    确实这样,应学习

    0

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