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Gastroenterology:肠易激综合征患者肠道微生物变化研究

2019-04-10 MedSci MedSci原创

研究认为,IBS患者的特异性微生物群落存在变化,但仍需要进行研究来确定这些微生物变化是肠易激综合征的结果还是病因

肠易激综合征(IBS)常见但难以治疗。改变肠道微生物群被认为是治疗IBS的策略之一,但肠道微生物群与IBS症状之间的关系尚未得到充分证实。近日研究人员开展系统综述和荟萃分析研究考察二者的相关性。

研究人员搜索了截至2018年4月2日Medline、EMBASE、Cochrane CDSR和Central等数据库相关研究,比较成人或儿童IBS患者粪便或结肠微生物与健康个体(对照组)的差异。

本次研究总计包含2631篇引文,24个临床研究。大多数研究评估成人的各种IBS亚型。与对照组相比,IBS患者肠杆菌科(Phylum蛋白菌)、乳杆菌科和拟杆菌属增加,而梭状芽孢杆菌I、粪便杆菌属细菌 (包括粪杆菌Prausnitzii)和双歧杆菌属则明显减少。IBS患者与对照组相比,微生物多样性有下降或无显著性差异。超过40%的研究没有说明病例和对照组是否具有可比性(无性别和/或年龄特征描述)。

研究认为,IBS患者的特异性微生物群落存在变化,但仍需要进行研究来确定这些微生物变化是肠易激综合征的结果还是病因。

原始出处:

Rapat Pittayanon et al. Gut Microbiota in Patients With Irritable Bowel Syndrome-a Systematic Review. Gastroenterology. March 30, 2019.

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    2019-08-15 许安
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