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Nutrients:肠癌为什么会增加?跟这种吃法大有关系!

2019-07-21 e药环球 e药环球

结直肠癌是全球第三大常见癌症,并且e药环球之前的文章也介绍过,年轻人中的结直肠癌发病率在上升。大家知道,结直肠癌跟饮食有很大关系。近期发表在《营养素》(Nutrients)杂志的一项研究揭示了一种饮食模式与结直肠癌的发病风险升高有关。

直肠癌是全球第三大常见癌症,并且e药环球之前的文章也介绍过,年轻人中的直肠癌发病率在上升。大家知道,结直肠癌跟饮食有很大关系。近期发表在《营养素》(Nutrients)杂志的一项研究揭示了一种饮食模式与结直肠癌的发病风险升高有关。

与结直肠癌的关系

在这项最新研究中,科学家们通过膳食炎症指数(DII)和非酶抗氧化能力(NEAC)对人群进行了专门的分析。DII和NEAC分别用于评估饮食的促炎症和抗氧化作用,是两个经过验证的有用工具。DII高,说明这种饮食的促炎症作用强;NEAC高,说明这种饮食的抗氧化能力强。这项研究利用了西班牙12个省的数据,共纳入1852例结直肠癌和1567例乳腺癌患者,对照组分别为3447例和1487例。

研究结果显示,DII评分高,以及NEAC评分低,与结直肠癌风险相关。“也就是说,采取炎症饮食的受试者患结直肠癌的风险几乎是其他人的两倍。”研究作者、西班牙加泰罗尼亚肿瘤研究所Mireia Obón博士解释道。

炎症饮食通常以食用精制碳水化合物、红肉和加工肉类,以及饱和或反式脂肪为特征。而在抗氧化饮食中,蔬菜、豆类、水果和坚果的摄入量占主导地位。“在这项研究中,我们关注的是饮食的作用,特别是它的炎症和抗氧化作用,因为有证据表明,慢性炎症和氧化应激都会影响这两种癌症的发生。”另一位作者Víctor Moreno博士说。

“食用促炎症和促氧化的饮食是结直肠癌的一个非常重要的危险因素。好在,这是一个可以改变的因素。”Mireia Obón博士强调,“我们应该重新调整我们的饮食习惯,转向地中海饮食,这种饮食模式富含水果和蔬菜、坚果、全谷物和橄榄油等健康油脂,同时我们应该远离较容易引发炎症的饮食。”

不过,Mireia Obón博士也指出:“我们没有发现乳腺癌风险的显著增加。所以我们还需要进行更多的研究,以检查是否真的与其他因素有相关性。”

为什么炎症饮食会有健康风险?

当身体识别出任何外来的东西,比如入侵的微生物、植物花粉或化学物质时,免疫系统就会被激活。这通常会引发一个叫做炎症的过程。针对真正有威胁的入侵者,不时发生的炎症会保护人的健康。

然而,有时即使没有受到外来入侵者的威胁,炎症也会一天又一天地持续。这时炎症就会成为身体的敌人。许多困扰我们的重要疾病,包括癌症、心脏病、糖尿病、关节炎、抑郁症和老年痴呆症,都与慢性炎症有关。

炎症饮食中的那些食物通常就被认为对我们的健康有害,包括碳酸饮料和精制碳水化合物,以及红肉和加工肉类。

“一些与升高2型糖尿病和心脏病等慢性疾病风险有关的食物,也与过度炎症有关。”哈佛大学公共卫生学院营养学系教授胡丙长(Frank Hu)博士说,“这并不奇怪,因为炎症是这些疾病发生的重要潜在机制。”

不健康的食物也会导致体重增加,而体重增加本身就是炎症的危险因素。然而,在一些研究中,即使在研究人员对肥胖因素进行调整后,食物和炎症之间的相关性仍然存在,这表明体重增加并不是唯一的驱动因素。胡博士说:“一些食物成分可能对炎症有独立的影响,而不仅仅是增加了热量的摄入。”

引起炎症的食物(应尽量避免或限制这些食物)包括:

精制碳水化合物,如白面包和油酥糕点等

炸薯条和其他油炸食品等

碳酸饮料和其他含糖饮料(参见:还能喝吗?超10万人研究显示含糖饮料或增癌症风险,每天多喝100ml,与癌症风险升高18%有关)

红肉(汉堡包、牛排)和加工肉类(热狗、香肠)

人造黄油、起酥油和猪油

为什么要选择抗炎症饮食?

胡博士指出:“许多实验研究表明,一些食物或饮料的成分可能具有抗炎作用。”

选对抗炎症食物,可能会减少患病的风险。如果总是选择错误的食物,就可能会加速炎症的过程。

胡博士说,一些饮料和食物可以减少炎症,还可以减少慢性病。他特别提到了水果和蔬菜,如蓝莓、苹果和绿叶蔬菜,它们富含天然抗氧化剂和植物中发现的多酚,这些都是植物中具有保护作用的化合物。

研究还发现,坚果与炎症指标降低,以及心血管疾病和糖尿病风险降低有关。咖啡含有多酚和其他抗炎化合物,也可能具有预防炎症的作用。

胡博士还指出:“健康的饮食不仅有利于降低患慢性病的风险,还有助于改善情绪和整体生活质量。”

怎样选择抗炎症饮食?

为了减轻炎症程度,应制定一个总体的健康饮食计划。如果你正在寻找一个符合抗炎症饮食原则的饮食计划,可以考虑一下地中海饮食,它富含水果、蔬菜、坚果、全谷物、鱼类和健康油脂。

抗炎症饮食包括以下食物:

西红柿

橄榄油

绿叶蔬菜,如菠菜、甘蓝和羽衣甘蓝等

坚果,如杏仁和核桃等

富含脂肪的鱼类,如鲑鱼、鲭鱼、金枪鱼和沙丁鱼等

水果,如草莓、蓝莓、樱桃和橙子等

原始出处:
Mireia Obón-Santacana, Dora Romaguera, Esther Gracia-Lavedan, et al. Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study). Nutrients. 21 Jun 2019.

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    2019-08-01 14692b62m40暂无昵称

    最后罗列的应该是抗氧化饮食

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    2019-07-26 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

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    2019-07-22 龙胆草

    学习谢谢分享

    0

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    2019-07-22 thm112988

    0

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    2019-07-21 130****4638

    健康饮食是唯一之道。

    0

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    2019-07-21 txqjm

    谢谢了,学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=370602, encodeId=51243e06020d, content=最后罗列的应该是抗氧化饮食, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dd995149497, createdName=14692b62m40暂无昵称, createdTime=Thu Aug 01 10:08:20 CST 2019, time=2019-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370305, encodeId=33103e0305fd, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jul 26 21:59:15 CST 2019, time=2019-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370095, encodeId=548d3e00956b, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Jul 22 08:50:09 CST 2019, time=2019-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370086, encodeId=a3773e00863c, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Mon Jul 22 07:19:07 CST 2019, time=2019-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370034, encodeId=ee4a3e0034ec, content=健康饮食是唯一之道。, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sun Jul 21 06:34:50 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370033, encodeId=79683e003328, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Sun Jul 21 06:34:45 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370028, encodeId=63583e002833, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sun Jul 21 06:11:18 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370025, encodeId=26223e002588, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sun Jul 21 03:55:30 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370022, encodeId=f2403e0022ee, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Jul 21 00:51:41 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370021, encodeId=2a6d3e002166, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Sun Jul 21 00:50:44 CST 2019, time=2019-07-21, status=1, ipAttribution=)]
    2019-07-21 yjs木玉

    好好好好好好

    0

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  9. [GetPortalCommentsPageByObjectIdResponse(id=370602, encodeId=51243e06020d, content=最后罗列的应该是抗氧化饮食, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dd995149497, createdName=14692b62m40暂无昵称, createdTime=Thu Aug 01 10:08:20 CST 2019, time=2019-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370305, encodeId=33103e0305fd, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jul 26 21:59:15 CST 2019, time=2019-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370095, encodeId=548d3e00956b, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Jul 22 08:50:09 CST 2019, time=2019-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370086, encodeId=a3773e00863c, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Mon Jul 22 07:19:07 CST 2019, time=2019-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370034, encodeId=ee4a3e0034ec, content=健康饮食是唯一之道。, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sun Jul 21 06:34:50 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370033, encodeId=79683e003328, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Sun Jul 21 06:34:45 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370028, encodeId=63583e002833, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sun Jul 21 06:11:18 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370025, encodeId=26223e002588, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sun Jul 21 03:55:30 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370022, encodeId=f2403e0022ee, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Jul 21 00:51:41 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370021, encodeId=2a6d3e002166, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Sun Jul 21 00:50:44 CST 2019, time=2019-07-21, status=1, ipAttribution=)]
    2019-07-21 飛歌

    学习了很有用不错

    0

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    2019-07-21 329523732

    不错

    0

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近日,广州市康立明生物科技有限责任公司(以下简称“康立明生物”)宣布完成3亿元人民币的B轮融资,由鼎晖投资、IDG资本投资,原股东辰德资本和金阖、金垣基金跟投,本轮资金将用于“长安心”产品上市后市场推广和后续癌肿产品管线的持续开发。

95%的肠癌是息肉惹的祸 这样做轻松阻断它的癌变之路!

结直肠癌的发生发展是一个多阶段的漫长过程,研究发现,近95%的结直肠癌是由息肉演变而来,经历正常粘膜→增生→腺瘤形成→腺瘤癌变的过程,一般需要5~10年的时间。

肠癌的癌前疾病——肠息肉都有哪些类型?是否都需要及时切除?

最保险的做法就是发现肠息肉后及时内镜下切除。

MSS型肠癌免疫联合靶向探索——从作用机制到临床研究

微卫星稳定(MSS)型肠癌约占晚期肠癌的95%,这类患者的免疫治疗一直是难以破解的困局。不同于微卫星高度不稳定(MSI-H)/错配修复基因缺失(dMMR)型肿瘤,免疫治疗对MSS型肠癌几乎无效,如何将这类肿瘤从“冷肿瘤”变为“热肿瘤”,是业界正在探索的方向。今年ASCO年会上公布的一项Ⅰb期研究REGONIVO,以瑞戈非尼联合纳武利尤单抗,为MSS肠癌带来了33%的客观缓解率,MSS型肠癌免疫治疗

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