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JACC Heart Failure:心律失常史或可影响急性心力衰竭时充血减轻轨迹

2019-01-19 国际循环编辑部 国际循环

临床实践中,心房颤动(AF)和/或心房扑动(AFL)与慢性心力衰竭(HF)常共存。但人们对AF和/或AFL对急性心力衰竭(AHF)患者充血减轻过程的影响知之甚少。近期,JACC: Heart Failure发表的一项最新研究专门根据AF/AFL病史情况观察AHF住院患者充血减轻过程的特征。

临床实践中,心房颤动(AF)和/或心房扑动(AFL)与慢性心力衰竭(HF)常共存。但人们对AF和/或AFL对急性心力衰竭(AHF)患者充血减轻过程的影响知之甚少。近期,JACC: Heart Failure发表的一项最新研究专门根据AF/AFL病史情况观察AHF住院患者充血减轻过程的特征。



研究对三项有关AHF的随机临床试验DOSE研究、ROSE研究及CARRESS-HF研究共计750例患者进行汇集分析,采用协变量校正后的线性及定序Logistic回归模型评估AF/AFL病史与各种充血指标住院期间变化的相关性。受试患者中,共计418例(56%)有AF/AFL病史。与无AF/AFL病史者相比,有AF/AFL病史者左心室射血分数更高(35% vs. 27%,P<0.001),NT-Pro BNP水平呈非显著性降低(4210 pg/ml vs. 5037 pg/ml,P=0.27)。

校正相关协变量后,AF/AFL病史与入院72 h或96 h内较不显著的体重减轻(-5.7% vs. -6.5%,P=0.02)和NT- proBNP水平降低(−18.7% vs. −31.3%,P=0.003)具有相关性。此外,AF/AFL病史还与72 h或96 h的总体幸福感增加较少(P=0.04)相关。但AF/AFL病史与orthodema充血评分变化(P=0.67)、60天复合临床终点(全因死亡率或全因再住院:HR=1.21,95%CI:0.92~1.59;P=0.17)并无相关性。

综上可见,临床实践中,超过50%的AHF住院患者有AF/AFL病史。AF/AFL病史与住院期间充血减轻过程较慢具有独立相关性。未来,有必要进一步研究确定AHF患者住院期间以AF/AFL为靶点的特定治疗的疗效。

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    2019-11-07 amy0550
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    2019-02-26 hbwxf
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    2019-01-21 智慧医人
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    2019-01-21 zhaojie88
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    2019-01-21 slcumt

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