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NEJM:慢性溃疡虽小,当心癌变!

2015-07-31 MedSci译 MedSci原创

女性,53岁,在其右手有一处久未愈合的伤口。据该女士主诉,在1年前曾做过疣去除激光术,术后该部位出现溃疡,导致至今未愈合。其过往无其他的病史,包括慢性炎症病史。6个月前,该女士被这诊断为患有坏疽性脓皮病,并采取接受局部和全身性的免疫制剂治疗,如口服糖皮质激素等,但症状并没有很大的改善。今日来诊后,从溃疡部位取活体组织作检查,结果显示为鳞状细胞癌。鳞状细胞癌最常见的相关危险因素包括年龄增长、皮肤颜色

女性,53岁,在其右手有一处久未愈合的伤口。


据该女士主诉,在1年前曾做过疣去除激光术,术后该部位出现溃疡,导致至今未愈合。其过往无其他的病史,包括慢性炎症病史。



6个月前,该女士被这诊断为患有坏疽性脓皮病,并采取接受局部和全身性的免疫制剂治疗,如口服糖皮质激素等,但症状并没有很大的改善。

今日来诊后,从溃疡部位取活体组织作检查,结果显示为鳞状细胞癌。

鳞状细胞癌最常见的相关危险因素包括年龄增长、皮肤颜色、紫外线照射、慢性免疫抑制和暴露于电离辐射等。其中,过多地暴露于紫外线诱发鳞状细胞癌的风险远远高于其他的相关危险因素,而照射的剂量和照射的面积大小是主要的影响因素,尤其最关键的头部。

该女士称,她的职业是一名乳房钼靶检查的助理,目前已经工作了几年,但是她一直以来都有做好基本辐射防护措施。

针对她的情况,医生决定对其进行局部切除手术以进行治疗。不幸的是,6个月后,她出现了复发的迹象。随后,再次进行局部切除术和放疗。

原始出处:

Emmert S, Schön MP.Squamous-Cell Carcinoma Resembling Pyoderma Gangrenosum. N Engl J Med. 2015 Jul 30;373(5):e5.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=34595, encodeId=8485345957d, content=跟工作也有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Wed Aug 05 18:49:00 CST 2015, time=2015-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34529, encodeId=9c0134529d6, content=小病不能忽视啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b159816, createdName=shneye, createdTime=Wed Aug 05 11:39:00 CST 2015, time=2015-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34294, encodeId=6a7d34294d4, content=必须重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Tue Aug 04 00:32:00 CST 2015, time=2015-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557032, encodeId=ce12155e0327e, content=<a href='/topic/show?id=154be128170' target=_blank style='color:#2F92EE;'>#癌变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71281, encryptionId=154be128170, topicName=癌变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7914850828, createdName=axin014, createdTime=Sun Aug 02 13:14:00 CST 2015, time=2015-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34005, encodeId=cdbb3400585, content=临床上还是见到不少长期的慢性炎症及溃疡导致的癌变, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Sat Aug 01 17:37:00 CST 2015, time=2015-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34002, encodeId=1fcd3400264, content=哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Sat Aug 01 16:54:00 CST 2015, time=2015-08-01, status=1, ipAttribution=)]
    2015-08-05 lovejing

    跟工作也有关

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=34595, encodeId=8485345957d, content=跟工作也有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Wed Aug 05 18:49:00 CST 2015, time=2015-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34529, encodeId=9c0134529d6, content=小病不能忽视啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b159816, createdName=shneye, createdTime=Wed Aug 05 11:39:00 CST 2015, time=2015-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34294, encodeId=6a7d34294d4, content=必须重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Tue Aug 04 00:32:00 CST 2015, time=2015-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557032, encodeId=ce12155e0327e, content=<a href='/topic/show?id=154be128170' target=_blank style='color:#2F92EE;'>#癌变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71281, encryptionId=154be128170, topicName=癌变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7914850828, createdName=axin014, createdTime=Sun Aug 02 13:14:00 CST 2015, time=2015-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34005, encodeId=cdbb3400585, content=临床上还是见到不少长期的慢性炎症及溃疡导致的癌变, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Sat Aug 01 17:37:00 CST 2015, time=2015-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34002, encodeId=1fcd3400264, content=哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Sat Aug 01 16:54:00 CST 2015, time=2015-08-01, status=1, ipAttribution=)]
    2015-08-05 shneye

    小病不能忽视啊

    0

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    2015-08-04 byzh1990

    必须重视

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=34595, encodeId=8485345957d, content=跟工作也有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Wed Aug 05 18:49:00 CST 2015, time=2015-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34529, encodeId=9c0134529d6, content=小病不能忽视啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b159816, createdName=shneye, createdTime=Wed Aug 05 11:39:00 CST 2015, time=2015-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34294, encodeId=6a7d34294d4, content=必须重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Tue Aug 04 00:32:00 CST 2015, time=2015-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557032, encodeId=ce12155e0327e, content=<a href='/topic/show?id=154be128170' target=_blank style='color:#2F92EE;'>#癌变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71281, encryptionId=154be128170, topicName=癌变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7914850828, createdName=axin014, createdTime=Sun Aug 02 13:14:00 CST 2015, time=2015-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34005, encodeId=cdbb3400585, content=临床上还是见到不少长期的慢性炎症及溃疡导致的癌变, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Sat Aug 01 17:37:00 CST 2015, time=2015-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34002, encodeId=1fcd3400264, content=哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Sat Aug 01 16:54:00 CST 2015, time=2015-08-01, status=1, ipAttribution=)]
    2015-08-02 axin014
  5. [GetPortalCommentsPageByObjectIdResponse(id=34595, encodeId=8485345957d, content=跟工作也有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Wed Aug 05 18:49:00 CST 2015, time=2015-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34529, encodeId=9c0134529d6, content=小病不能忽视啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b159816, createdName=shneye, createdTime=Wed Aug 05 11:39:00 CST 2015, time=2015-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34294, encodeId=6a7d34294d4, content=必须重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Tue Aug 04 00:32:00 CST 2015, time=2015-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557032, encodeId=ce12155e0327e, content=<a href='/topic/show?id=154be128170' target=_blank style='color:#2F92EE;'>#癌变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71281, encryptionId=154be128170, topicName=癌变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7914850828, createdName=axin014, createdTime=Sun Aug 02 13:14:00 CST 2015, time=2015-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34005, encodeId=cdbb3400585, content=临床上还是见到不少长期的慢性炎症及溃疡导致的癌变, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Sat Aug 01 17:37:00 CST 2015, time=2015-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34002, encodeId=1fcd3400264, content=哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Sat Aug 01 16:54:00 CST 2015, time=2015-08-01, status=1, ipAttribution=)]
    2015-08-01 DocterSunshine

    临床上还是见到不少长期的慢性炎症及溃疡导致的癌变

    0

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    2015-08-01 zm0805

    0

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众所周知,质子泵抑制剂可用于预防非甾体抗炎药(NSAID)引起的胃肠道不良事件。然而在日本,关于这种治疗方法的疗效和安全性的数据还很少。为了评估日本高危患者应用埃索美拉唑预防NSAID引起的消化性溃疡的的疗效和耐受性。研究者招募了胃镜证实有溃疡病史,并且需要长期口服NSAID治疗慢性炎症的日本成年(≥20岁)患者,将其随机分组,给予埃索美拉唑20 mg/d或安慰剂,共24周。主要终点是Kaplan

Gut:Tralokinumab能有效缓解中重度溃疡性结肠炎

白细胞介素13(IL-13)被认为是炎症性肠病溃疡性结肠炎的一个关键驱动因素。白细胞介素13的中和抗体Tralokinumab已被临床试验证实能够改善严重哮喘患者肺功能,但其是否对成人中重度溃疡性结肠炎患者同样安全、有效目前尚不清楚。最近,来自意大利、波兰、德国等多国际研究中心的科学家们进行了一项编号为NCT01482884的随机、双盲、安慰剂对照的IIa期临床试验,在成人中重度溃疡性结肠炎标准治

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据报道,糖尿病患者有较高的消化性溃疡发病率。为探讨2型糖尿病患者是否有较高的消化性溃疡出血(PUB)发病风险,并确定其发生PUB可能的危险因素,来自台湾台北荣民总医院的Yen-Ling Peng教授及其团队进行了一项研究。研究发现,2型糖尿病患者发生PUB的风险显着升高。该研究结果发表在2013年8月的Journal of Gastroenterology and Hepa

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