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JAHA:动脉顺应性与冠心病发生风险存在性别差异!

2017-08-20 MedSci MedSci原创

冠心病是女性健康的头号杀手,动脉的硬化程度可以预测心肌的梗塞,而绝经后女性的动脉顺应性(AC)较男性处于低水平。近日,在国际心血管权威杂志JAHA上发表了一篇旨在AC与冠脉栓塞和钙化在女性中的相关性的临床研究。本研究纳入了3639名无冠心病病史的成年人,冠脉的钙化程度通过Agatston法进行评估,AC指数通过心搏量指数/中心脉压来算得,并利用多元线性回归分析评估logAC指数与log(冠脉钙化评

冠心病是女性健康的头号杀手,动脉的硬化程度可以预测心肌的梗塞,而绝经后女性的动脉顺应性(AC)较男性处于低水平。近日,在国际心血管权威杂志JAHA上发表了一篇旨在AC与冠脉栓塞和钙化在女性中的相关性的临床研究。

本研究纳入了3639名无冠心病病史的成年人,冠脉的钙化程度通过Agatston法进行评估,AC指数通过心搏量指数/中心脉压来算得,并利用多元线性回归分析评估logAC指数与log(冠脉钙化评分+1)和log(斑块百分比评分+1)之间的相关性。最终纳入研究对象的平均年龄为57±11岁,男性占53%,71%患有高血压。结果显示在女性中,低AC指数与高的冠脉钙化评分和斑块百分比评分呈相关性(β±SE: -0.231±0.113, P=0.042 ; -0.334±0.166, P=0.044),而在男性中不呈明显相关(β±SE: -0.062±0.104, P=0.551; 0.114±0.173, P=0.510,)。

研究结果表明,低的动脉顺应性在女性中与冠脉钙化和斑块形成呈明显相关性,而在男性中不存在相关性。换句话说,在女性中,低水平的动脉顺应性与不良心血管事件发生风险呈相关性。

原始出处:

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    2017-08-22 zhaohui6731
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    2017-08-21 flysky120

    学习一下知识

    0

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    2017-08-21 130****4638

    学习了受益匪浅

    0

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    2017-08-21 明月清辉

    谢谢分享,学习了

    0

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    2017-08-21 1e17414fm02(暂无匿称)

    学习

    0

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    2017-08-20 王秀

    学习了,涨知识了!

    0

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    2017-08-20 楠博One

    学习谢谢分享

    0

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