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CLIN CANCER RES：RNF6与结直肠癌不良预后有关

2018-03-28 MedSci MedSci原创

结直肠癌RNF6不良预后
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RNF6在肿瘤发生过程中起到重要作用，但是关于结直肠癌中RNF6拷贝数及表达的报道很少。CLIN CANCER RES近期发表了一篇文章，研究RNF6在结直肠癌发生发展过程中的作用。

RNF6在肿瘤发生过程中起到重要作用，但是关于结直肠癌中RNF6拷贝数及表达的报道很少。CLIN CANCER RES近期发表了一篇文章，研究RNF6在结直肠癌发生发展过程中的作用。

作者通过公共数据库研究了RNF6的拷贝数和表达情况。通过rt-PCR，Western blot和免疫组化染色等验证基因表达情况。在体内和体外实验中研究RNF6对肿瘤生长和转移的影响。利用免疫共沉淀和共聚焦显微镜研究RNF6在调节SHP-1表达中发挥的作用。研究结果发现，结直肠癌中RNF6拷贝数显着扩增，该扩增与RNF6表达水平有关。RNF6扩增和过表达与结直肠癌患者不良预后显着相关。基因富集分析表明RNF6高表达的结直肠癌中增殖和侵袭相关基因增加。在体内和体外实验中下调RNF6表达会损伤结直肠癌细胞增殖和侵袭能力。RNF6可能通过诱导SHP-1泛素化和降解激活JAK/STAT3通路，增加pSTAT3水平。

文章最后认为，结直肠癌中基因扩增促进RNF6过表达。RNF6在结直肠癌进展过程中可能成为重要的生物学标志，RNF6通过促进SHP-1泛素化和降解增加pSTAT3水平。靶向RNF6/SHP/STAT3轴为治疗RNF6扩增肿瘤提供了新的选择。

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    2018-04-12 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

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    2018-04-02 jihuaijun1112

    学习学习学习

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    2018-04-01 jihuaijun1112

    学习学习学习

    0

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    2018-03-31 天地飞扬

    了解一下.谢谢分享!

    0

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    2018-03-31 jihuaijun1112

    学习学习学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=305112, encodeId=de1130511231, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Apr 12 14:25:04 CST 2018, time=2018-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301873, encodeId=294f3018e3cb, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Apr 02 00:20:12 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301605, encodeId=e57930160533, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sun Apr 01 02:21:58 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301573, encodeId=06c23015e316, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat Mar 31 23:08:20 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301332, encodeId=56573013320e, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sat Mar 31 01:31:46 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336363, encodeId=67cd13363639b, content=<a href='/topic/show?id=071820530c5' target=_blank style='color:#2F92EE;'>#不良预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20530, encryptionId=071820530c5, topicName=不良预后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Fri Mar 30 12:09:00 CST 2018, time=2018-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453100, encodeId=16f01453100b9, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Fri Mar 30 12:09:00 CST 2018, time=2018-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300559, encodeId=54e5300559ac, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Mar 28 21:33:36 CST 2018, time=2018-03-28, status=1, ipAttribution=)]
    2018-03-30 thinkibmz_44722594

    #不良预后#

    0

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    2018-03-30 crystal0564

    #结直肠#

    0

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    2018-03-28 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

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