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ADA 2016:载脂蛋白B偏高的孕妇应警惕后代心血管风险

2016-06-13 Seven L 译 MedSci原创

据美国糖尿病协会科学会议的数据显示,目前的载脂蛋白B升高,那么其后代将有六倍的可能性也是载脂蛋白B(Apo B)升高。布宜诺斯艾利斯杜兰医院的研究者Valeria Hirschler博士和同事对84名儿童(男孩占42名,平均年龄5.3岁)母亲(平均年龄33.8岁)进行了研究。检测了参与者的BMI、腰围、血脂水平、Apo B、Apo A等指标。数据显示,儿童中有24.4%的为超重,11.5%的为肥胖

据美国糖尿病协会科学会议的数据显示,目前的载脂蛋白B升高,那么其后代将有六倍的可能性也是载脂蛋白B(Apo B)升高。

布宜诺斯艾利斯杜兰医院的研究者Valeria Hirschler博士和同事对84对儿童(男孩占42名,平均年龄5.3岁)和母亲(平均年龄33.8岁)进行了研究。检测了参与者的BMI、腰围、血脂水平、Apo B、Apo A等指标。

数据显示,儿童中有24.4%的为超重,11.5%的为肥胖;母亲里则有39.1%的为超重,以及39.1%的肥胖。当Apo B水平高于第三个四分位77.6mg/dl时,定义为高Apo B水平。

与Apo B水平第三四分位数的母亲的孩子相比,具有高Apo B水平的母亲的儿童有显着较高的BMI z评分 (0.4 vs. 1.2)、腰围(55cm vs. 58cm)、低密度脂蛋白胆固醇(LDL-C)(79mg/dl vs. 98mg/dl)与Apo B水平(73.9 mg/dL vs. 92.5 mg/dL)。

校正年龄、性别和BMI后,具有高Apo B水平的母亲的儿童发生高Apo B水平的OR=5.7(95% CI, 1.3-25.5)。

研究者认为,目前对心血管疾病的风险检测和临床发现具有较长的滞后,如果通过母亲的Apo B水平评估后代情况,就有可能更早的为后代提供干预,降低风险。

原始出处:

Hirschler V, et al. 1277-P. Presented at: American Diabetes Association Scientific Sessions; June 10-14, 2016; New Orleans.

High maternal apolipoprotein B may indicate increased CV risk in children.Healio.June 12, 2016


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    2016-06-15 般若傻瓜
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来源:医学论坛网   瑞典一项研究表明,载脂蛋白和抗磷酰胆碱(PC)抗体可能在类风湿关节炎(RA)患者发生亚临床动脉粥样硬化中发挥独立作用。该研究论文7月9日在线发表在《风湿病学》(Rheumatology)杂志。   该研究共纳入115例近期发生RA(症状发作后<12个月)患者,年龄平均50.6±11.2岁,68.4%女性,并在RA确诊后评估患者基线、3、12、24和60个月的病情。研究在同

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