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Sci Rep:脑脊液miRNA或可用于预测颞叶癫痫和癫痫持续状态

2017-08-08 MedSci MedSci原创

需要癫痫和癫痫持续状态的诊断生物标志物来支持临床检查、脑电图和神经成像。细胞外miRNA可能是潜在的理想生物标志物,因为某些miRNA在特定的脑区域和细胞类型中是独特存在的。脑脊液可提供miRNA生物标志物的来源,其优点是与靶组织和病理部位紧密接触。在这里,研究人员分析了患有颞叶癫痫或癫痫持续状态患者脑脊液中的microRNA水平,并将结果与匹配对照进行了比较。结果显示,患者组和对照组之间有20个

需要癫痫和癫痫持续状态的诊断生物标志物来支持临床检查、脑电图和神经成像。细胞外miRNA可能是潜在的理想生物标志物,因为某些miRNA在特定的脑区域和细胞类型中是独特存在的。脑脊液可提供miRNA生物标志物的来源,其优点是与靶组织和病理部位紧密接触。

在这里,研究人员分析了患有颞叶癫痫或癫痫持续状态患者脑脊液中的microRNA水平,并将结果与匹配对照进行了比较。

结果显示,患者组和对照组之间有20个microRNAs差异表达。验证阶段包括扩大的队列和患有其他神经疾病的患者的样本。结果发现,与对照组、癫痫持续状态和其他神经系统疾病相比,颞叶癫痫患者的miR-19b水平较低。与其他组相比,癫痫持续状态组miR-451a的水平较高,而miR-21-5p水平在癫痫持续状态下与颞叶癫痫不同,而与其他神经系统疾病无差别。这些microRNA的目标包括调节神经元死亡,组织重塑,神经胶质增生和炎症的蛋白质。

总之,该研究表明,脑脊髓液含有可支持颞叶癫痫和癫痫持续状态与其他神经和非神经疾病鉴别诊断的微小RNA。

原始出处:

Rana Raoof, Eva M. Jimenez-Mateos, et al., Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus. Sci Rep. 2017; 7: 3328. Published online 2017 Jun 12. doi:  10.1038/s41598-017-02969-6.

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    2017-09-09 smallant2002
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    2017-08-10 Homburg
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    2017-08-09 QQ25ed180f

    脑脊液生化检查的判读在临床运用广。

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