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Diabetologia：GLP-1信号传导补偿βIRKO小鼠调节β细胞增殖的胰岛素信号受损

2017-08-01 MedSci MedSci原创

糖尿病管理
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近日，国际杂志 《Diabetologia》上在线发表一项关于GLP-1信号传导补偿βIRKO小鼠调节β细胞增殖的胰岛素信号受损的研究。研究旨在调查胰岛素和胰高血糖素样肽（GLP）-1信号通路之间在调节体内β细胞周期动力学中的潜在相互作用，在glp - 1治疗潜力的背景下，调节受损细胞的功能。

近日，国际杂志 《Diabetologia》上在线发表一项关于GLP-1信号传导补偿βIRKO小鼠调节β细胞增殖的胰岛素信号受损的研究。研究旨在调查胰岛素和胰高血糖素样肽（GLP）-1信号通路之间在调节体内β细胞周期动力学中的潜在相互作用，在glp - 1治疗潜力的背景下，调节受损细胞的功能。 研究用二肽基肽酶-4抑制剂维格列汀处理β细胞特异性胰岛素受体敲除（βIRKO）小鼠，该小鼠β细胞功能障碍和β细胞量的年龄依赖性降低。此后，评估了葡萄糖体内平衡和β细胞增殖，并研究了潜在的分子机制。 研究人员通过用维格列汀处理6周的敲除小鼠引起的循环GLP-1水平的持续升高显著改善葡萄糖耐量仅次于增强的胰岛素分泌和β细胞的增殖。除了细胞周期蛋白D2之外，用GLP-1类似物、毒蜥外泌肽-4处理βIRKOβ细胞系，促进Akt磷酸化和细胞周期蛋白A，D1和E的蛋白质表达两到三倍。维格列汀处理的βIRKO小鼠的胰腺显示细胞周期蛋白D1表达增加，而细胞周期蛋白D2表达受损。 研究表明，GLP-1信号的激活补偿受损的生长因子（胰岛素）信号并增强细胞周期蛋白的表达以促进β细胞增殖。总之，这些数据表明潜在的GLP

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    2017-10-11 baoya

    #胰岛#

    0

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    2018-06-22 ms5439512287675881

    #BET#

    0

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createdBy=f8f23732777, createdName=yibei, createdTime=Thu Aug 03 11:50:00 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540895, encodeId=639e1540895e8, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Thu Aug 03 11:50:00 CST 2017, time=2017-08-03, status=1, ipAttribution=)]
    2017-09-01 ms9608593228839890

    #DIA#

    0

  4. 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createdBy=f8f23732777, createdName=yibei, createdTime=Thu Aug 03 11:50:00 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540895, encodeId=639e1540895e8, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Thu Aug 03 11:50:00 CST 2017, time=2017-08-03, status=1, ipAttribution=)]
    2017-08-07 1e145228m78(暂无匿称)

    学习了，谢谢作:者分享!

    0

  5. 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createdBy=f8f23732777, createdName=yibei, createdTime=Thu Aug 03 11:50:00 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540895, encodeId=639e1540895e8, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Thu Aug 03 11:50:00 CST 2017, time=2017-08-03, status=1, ipAttribution=)]
    2017-08-05 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

  6. 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createdBy=f8f23732777, createdName=yibei, createdTime=Thu Aug 03 11:50:00 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540895, encodeId=639e1540895e8, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Thu Aug 03 11:50:00 CST 2017, time=2017-08-03, status=1, ipAttribution=)]
    2017-08-04 ylzr123

    感谢小编为我们精心准备了如此精辟的精神大餐，小编辛苦了，点个赞吧！

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon Aug 07 23:43:08 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230482, encodeId=8ba623048225, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Aug 05 23:28:48 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229843, encodeId=defc229843fd, content=感谢小编为我们精心准备了如此精辟的精神大餐，小编辛苦了，点个赞吧！, beContent=null, objectType=article, 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    2017-08-04 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

  8. 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createdBy=f8f23732777, createdName=yibei, createdTime=Thu Aug 03 11:50:00 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540895, encodeId=639e1540895e8, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Thu Aug 03 11:50:00 CST 2017, time=2017-08-03, status=1, ipAttribution=)]
    2017-08-03 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

  9. 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createdBy=f8f23732777, createdName=yibei, createdTime=Thu Aug 03 11:50:00 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540895, encodeId=639e1540895e8, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Thu Aug 03 11:50:00 CST 2017, time=2017-08-03, status=1, ipAttribution=)]
    2017-08-03 yibei

    #GLP-1#

    0

  10. 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    2017-08-03 晓辰

    #细胞增殖#

    0

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