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Ann Rheum Dis:类风湿关节炎联用他汀药物可有益生存

2016-08-30 Moon 译 MedSci原创

对类风湿关节炎(RA)联用他汀类降脂药和抗炎药物,可能有益于生存。然而,关于这一联系的数据是有限的,他汀类药物在类风湿性关节炎中的作用尚不清楚。 因此有研究者对一般人群中的类风湿性关节炎患者患者进行了研究,探究使用他汀类药物与总死亡率的关系。 使用英国总人口数据库的数据,我们进行了一项时间分层倾向得分匹配的队列研究。研究人群包括2000年1月至2012年12月期间诊断为RA的≥ 20岁

对类风湿关节炎(RA)联用他汀类降脂药和抗炎药物,可能有益于生存。然而,关于这一联系的数据是有限的,他汀类药物在类风湿性关节炎中的作用尚不清楚。

因此有研究者对一般人群中的类风湿性关节炎患者患者进行了研究,探究使用他汀类药物与总死亡率的关系。

使用英国总人口数据库的数据,我们进行了一项时间分层倾向得分匹配的队列研究。研究人群包括2000年1月至2012年12月期间诊断为RA的≥ 20岁至少使用过一种疾病修饰治疗风湿病的药物(DMARD)的患者。考虑到潜在混杂因素,研究人员比较了启动他汀类药物治疗和比较组(非起始者)的倾向得分匹配队列。

结果显示,在平均4.51 年随访期间,2943名启动他汀类药物治疗的患者发生了432例死亡,发生率为32.6/1000人年(PY);对照组2943名参与者中发生了513例死亡,发生率为40.6/1000PY。两组的基线特征是平衡的。分析数据显示,启动他汀类药物治疗与全因死亡率风险降低21%相关(HR=0.79, 95% CI 0.68 to 0.91)。当RA的诊断变为诊断编码定义时(不根据DMARD)相应的HR为0.81 (95% CI 0.74 to 0.90)。

结果表明,启动他汀类药物治疗与RA患者死亡率风险降低有关;且联系程度与之前在普通人群中进行的随机试验中观察到的相似。

原始出处:

Schoenfeld SR,et al.Statin use and mortality in rheumatoid arthritis: a general population-based cohort study.  Ann Rheum Dis 2016 Jul;75(7):1315-20

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    2016-10-11 1e10c84am36(暂无匿称)

    好文章,受益

    0

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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Thu Sep 01 02:34:00 CST 2016, time=2016-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597254, encodeId=c5c7159e254fe, content=<a href='/topic/show?id=fa1710082017' target=_blank style='color:#2F92EE;'>#风湿关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100820, encryptionId=fa1710082017, topicName=风湿关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=456818510265, createdName=xuruicheng, createdTime=Thu Sep 01 02:34:00 CST 2016, time=2016-09-01, status=1, ipAttribution=)]
    2016-09-15 doctorJiangchao

    继续关注

    0

  4. 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    2016-09-15 doctorJiangchao

    继续学习

    0

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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Thu Sep 01 02:34:00 CST 2016, time=2016-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597254, encodeId=c5c7159e254fe, content=<a href='/topic/show?id=fa1710082017' target=_blank style='color:#2F92EE;'>#风湿关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100820, encryptionId=fa1710082017, topicName=风湿关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=456818510265, createdName=xuruicheng, createdTime=Thu Sep 01 02:34:00 CST 2016, time=2016-09-01, status=1, ipAttribution=)]
    2016-09-14 doctorJiangchao

    继续学习了

    0

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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Thu Sep 01 02:34:00 CST 2016, time=2016-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597254, encodeId=c5c7159e254fe, content=<a href='/topic/show?id=fa1710082017' target=_blank style='color:#2F92EE;'>#风湿关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100820, encryptionId=fa1710082017, topicName=风湿关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=456818510265, createdName=xuruicheng, createdTime=Thu Sep 01 02:34:00 CST 2016, time=2016-09-01, status=1, ipAttribution=)]
    2016-09-14 doctorJiangchao

    继续关注

    0

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    2016-09-13 ylzr123

    赞一个!好文章拜读了,认真学习了。

    0

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    2016-09-01 lmm397
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