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Oral Dis:口服益生菌是否能有效治疗牙龈炎?

2022-06-01 sunshine MedSci原创

牙斑生物膜和宿主的免疫炎症反应共同促进了牙斑诱发的牙龈炎的发展。益生菌是能够维持微生态平衡并赋予宿主健康益处的活的微生物,这不仅包括重建微生物群落,还包括调节免疫-炎症反应。

牙斑生物膜和宿主的免疫炎症反应共同促进了牙斑诱发的牙龈炎的发展。益生菌是能够维持微生态平衡并赋予宿主健康益处的活的微生物,这不仅可以重建微生物群落,还可以调节免疫-炎症反应。在口腔方面,益生菌的有益作用包括改善生物膜的质量和调控宿主的炎症反应。近日,发表于Oral Dis的一项系统回顾和荟萃分析评估益生菌对斑块诱发的牙龈炎患者的牙龈炎症和口腔微生物群的影响。

研究人员检索了2020年12月PubMed、Cochrane中央对照试验注册中心(CENTRAL)和EMBASE数据库中收录的相关文章。纳入研究的质量使用Cochrane合作组织的偏见风险工具评估。差异以加权平均差异(WMD)和95%的置信区间(95% CI)表示。进行I2检验以评估研究的异质性。

结果,研究共纳入了11项随机和对照试验,包括554名患者。分析结果显示,口服益生菌并没有显著改善菌斑引起的牙龈炎患者的牙龈指数(GI)、菌斑指数(PI)和探诊出血(BOP)。在微生态学方面,益生菌组和安慰剂组在牙龈龈沟液(GCF)的、IL-1β的浓度以及放线聚集杆菌(Aa)、牙龈卟啉单胞菌(Pg)、中间普氏菌(Pi)和具核梭杆菌(Fn)的数量上没有发现明显的差异。

综上所述,该研究结果表明,目前没有明确的证据表明口服益生菌对牙龈炎症和菌斑诱发的牙龈炎患者的口腔微生态环境有积极作用。需要精心设计的RCTs进一步探究该问题以得出明确的结论。

原始出处:

Jiaxuan Liu, et al., Effect of probiotics on gingival inflammation and oral microbiota: A meta-analysis. Oral Dis. 2022 May;28(4):1058-1067. doi: 10.1111/odi.13861.  

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    2023-02-25 小几洁
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