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Br J Surg:左肝切除术后结局分析

2016-02-17 Mechront 译 MedSci原创

左肝三叶切除术(LHT)是十分具有挑战的解剖性肝切除术,全球范围内该手术的经验有限,术后并发症发生率尤其高。研究者对1993-2013年间进行了LHT的113名患者进行了一项队列研究,分析这些患者的预后,以及识别与术后长期和短期结局相关的因素。纳入研究的113名患者中有57名为结直肠癌肝转移,22名为肝门部胆管癌,12名为肝内胆管癌,11名为肝细胞性肝癌,还有11名患者有其他各种手术指征。整体上这

左肝三叶切除术(LHT)是十分具有挑战的解剖性肝切除术,全球范围内该手术的经验有限,术后并发症发生率尤其高。研究者对1993-2013年间进行了LHT的113名患者进行了一项队列研究,分析这些患者的预后,以及识别与术后长期和短期结局相关的因素。

纳入研究的113名患者中有57名为结直肠癌肝转移,22名为肝门部胆管癌,12名为肝内胆管癌,11名为肝细胞性肝癌,还有11名患者有其他各种手术指征。

整体上这113名患者术后的发病率和90天死亡率分别为46.0%和9.7%,术后1年和3年的生存率分别为71.3%和44.4%。分析后发现,全肝血流阻断和术中输血是术后并发症的独立预测因子,而输血是预测住院死亡率的唯一因素。时间段分析显示,在过去5年时间里,输血、住院时间、术后并发症和死亡率呈下降趋势。

研究结果表明,具有显著肿瘤负担的患者,LHT术后的发病率、死亡率和长期生存率支持LHT治疗方式的选择。

原始出处:

Farid SG, White A,et al.Clinical outcomes of left hepatic trisectionectomy for hepatobiliary malignancy.Br J Surg. 2016 Feb;103(3):249-56. doi: 10.1002/bjs.10059.


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    2016-03-13 DoctorTao1991

    挺新颖的观点

    0

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    2016-08-05 changfy
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