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HFSA 2016:多发性肌炎和皮肌炎患者,警惕心衰!

2016-09-29 Moon 译 MedSci原创

HFSA年会上的数据显示:多发性肌炎和皮肌炎患者的心血管危险因素和心衰发病率增加。 研究人员写道,虽然这一人群中传统的心血管危险因素明显增加,但是这些因素对心衰的发展会有什么影响? 研究人员多48502820例患者进行了回顾性分析,使用多机构的数据库,调查这类多发性肌炎和皮肌炎患者的心血管危险因素和心衰发病率等情况。 队列中多发性肌炎和皮肌炎分别有5980(0.012%)例和10

HFSA年会上的数据显示:多发性肌炎和皮肌炎患者的心血管危险因素和心衰发病率增加。

研究人员写道,虽然这一人群中传统的心血管危险因素明显增加,但是这些因素对心衰的发展会有什么影响?

研究人员多48502820例患者进行了回顾性分析,使用多机构的数据库,调查这类多发性肌炎和皮肌炎患者的心血管危险因素和心衰发病率等情况。

队列中多发性肌炎和皮肌炎分别有5980(0.012%)例和10420(0.021%)例。这类患者的心衰发病率显著增加(多发性肌炎, 4.68%;皮肌炎, 6.43%;对照组, 0.54%);随着年龄,心衰的绝对和相对风险也增加。

心衰风险方面,没有性别差异;但是炎性肌病在女性中更常见。

炎症性肌病与对照组相比,心血管危险因素更为常见,这些危险因素包括:高血压(66.8% vs. 16.7%)、糖尿病(45.9% vs. 6.5%)、吸烟(13.7% vs. 3.2%)、血脂异常(55.9% vs. 13.5%)、肥胖(24.7% vs. 5.2%)和CAD (25.6% vs. 4.4%)。

不仅如此,以下疾病也更常见于炎症性肌病患者:心瓣膜病(13.9% vs. 2.4%)、传导系统疾病(33.4% vs. 6.6%)、心肌炎(0.49% vs. 0.02%)和肺动脉高压(4.2% vs. 0.2%)。

多因素分析显示,炎性肌病是心力衰竭的独立危险因素(aOR 2.22; 95% CI, 2.08–2.37);炎性肌病对心衰风险的影响,超过以下因素:年龄(OR = 1.93; 95% CI: 1.92–1.95)、糖尿病(OR = 1.62; 95% CI: 1.60–1.63)、吸烟(OR = 1.45; 95% CI, 1.43–1.47)和血脂异常(OR = 1.86; 95% CI, 1.84–1.88);与肥胖对其的风险影响程度类似(OR = 2.23; 95% CI: 2.21–2.25);低于高血压(OR = 9.2; 95% CI, 9.06–9.35)和CAD对其的影响(OR = 4.59; 95% CI, 4.54–4.63)。

原始出处:

Kim CH, et al. Poster 049. Presented at: Heart Failure Society of America Scientific Assembly; Sept. 17-20, 2016; Orlando, Fla.

CV risk factors, HF increased in patients with polymyositis, dermatomyositis.Healio.September 28, 2016

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    2017-06-04 jml2009
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    2016-10-11 1e10c84am36(暂无匿称)

    好文章,受益

    0

  4. 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    2016-10-04 Carlos007

    研究人员多48502820例患者进行了回顾性分析!

    0

  5. 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    2016-10-04 Carlos007

    多发性肌炎和皮肌炎患者的心血管危险因素和心衰发病率增加!

    0

  6. 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href='/topic/show?id=e947e198270' target=_blank style='color:#2F92EE;'>#皮肌炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71982, encryptionId=e947e198270, topicName=皮肌炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat Oct 01 07:56:00 CST 2016, time=2016-10-01, status=1, ipAttribution=)]
    2016-10-04 Carlos007

    炎性肌病是心力衰竭的独立危险因素!

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Oct 02 17:00:19 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138464, encodeId=c48613846462, content=讲的好,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Oct 01 09:54:01 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309260, encodeId=ee871309260fb, content=<a href='/topic/show?id=e947e198270' target=_blank style='color:#2F92EE;'>#皮肌炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71982, encryptionId=e947e198270, topicName=皮肌炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat Oct 01 07:56:00 CST 2016, time=2016-10-01, status=1, ipAttribution=)]
    2016-10-02 doctorJiangchao

    继续关注

    0

  8. 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    2016-10-02 doctorJiangchao

    继续学习

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Oct 02 17:00:19 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138464, encodeId=c48613846462, content=讲的好,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Oct 01 09:54:01 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309260, encodeId=ee871309260fb, content=<a href='/topic/show?id=e947e198270' target=_blank style='color:#2F92EE;'>#皮肌炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71982, encryptionId=e947e198270, topicName=皮肌炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat Oct 01 07:56:00 CST 2016, time=2016-10-01, status=1, ipAttribution=)]
    2016-10-01 虈亣靌

    讲的好,学习了!

    0

  10. 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根据研究结果,同时发生系统性硬化症和多发性肌炎的患者,其生存会比仅有系统性硬化症患者更差。研究人员使用奈梅亨系统性硬化症队列确定了396例系统性硬化症(SSc)和24例同时发生系统性硬化症和多发性肌炎(SSc-PM)的患者。调查人员根据死亡人数和随访时间评估了生存率;使用Cox比例风险模型进行生存分析,比较SSc和SSc-PM患者的生存差异。结果表明,SSc患者的5年和10年累积生存率分别为93%

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