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FASEB J:科学家发现促进胰岛素分泌的蛋白质,效果惊人!

2017-07-11 sunshine2015 来宝网

在FASEB Journal杂志上发表的一项研究表明,通常已知用于阻止细胞功能的蛋白质复合物(Gbeta5-RGS)实际上可能刺激胰腺细胞中的胰岛素分泌。这一发现为身体无法产生足够水平的胰岛素(如糖尿病)的疾病提供了新的治疗策略的见解。



【Gbeta5-RGS蛋白刺激胰岛素分泌,另科学家惊讶】在FASEB Journal杂志上发表的一项研究表明,通常已知用于阻止细胞功能的蛋白质复合物(Gbeta5-RGS)实际上可能刺激胰腺细胞中的胰岛素分泌。这一发现为身体无法产生足够水平的胰岛素(如糖尿病)的疾病提供了新的治疗策略的见解。

迈阿密医学院(迈阿密,佛罗里达州)分子与细胞药理学系教授Vladlen Z. Slepak博士说:“再次,Gbeta5-RGS蛋白质继续令我们惊讶。 “这种复合物在胰岛素分泌中的作用与人们预期的完全相反,我们希望当前工作的见解将有助于我们了解和治疗这些基因破裂时发生的疾病。”

在他们的研究中,Slepak和他的同事分析了两组小鼠的胰岛素生成 - 一种是正常的,另一种是缺乏构建Gbeta5蛋白的基因的。他们发现,缺乏该基因的小鼠血液中存在的胰岛素少得多。然后研究人员对分离的胰岛(胰岛素产生器官)和细胞进行实验,并从中也删除了Gbeta5基因。结果清楚地表明,Gbeta5-RGS是刺激胰岛素分泌所必需的。当研究人员将基因重新置于原位时,胰岛素分泌恢复。

“FASEB杂志”总编辑Thoru Pederson博士说:“任何这样令人惊讶的结果令我们重新思考一些所谓的基础知识。”

原始出处:

Qiang Wang et al, Regulator of G protein signaling Gβ5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion, The FASEB Journal (2017). DOI: 10.1096/fj.201700197RR.

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    2017-12-04 gracezdd
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    2018-06-19 baoya
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  5. 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    2017-10-04 gwc392
  6. 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  7. 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  8. [GetPortalCommentsPageByObjectIdResponse(id=2057935, encodeId=2102205e93566, content=<a href='/topic/show?id=3836e24819' target=_blank style='color:#2F92EE;'>#FAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7248, encryptionId=3836e24819, topicName=FAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Mon Dec 04 21:53:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749782, encodeId=54941e49782f0, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Jul 12 16:22:43 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221332, encodeId=bde422133214, content=新知识,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYQJjaU2fLIb1yNqibkbdJs7gVIDr9xJyYeiapArSMjn3W61bPJtpIazSdAxRaFEOKYgfQjX4achN2d/0, createdBy=68472058812, createdName=日月生辉, createdTime=Wed Jul 12 08:00:59 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221173, encodeId=8e6e2211e326, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM7V1lG3lEERmrZh1ZAYgnIqsCAwFfLlOdXroVwBJqvTvw/0, createdBy=b2522082239, createdName=维维豆奶, createdTime=Tue Jul 11 22:52:04 CST 2017, time=2017-07-11, status=1, ipAttribution=)]
    2017-07-12 三生有幸9135

    学习一下谢谢分享

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Jul 12 16:22:43 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221332, encodeId=bde422133214, content=新知识,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYQJjaU2fLIb1yNqibkbdJs7gVIDr9xJyYeiapArSMjn3W61bPJtpIazSdAxRaFEOKYgfQjX4achN2d/0, createdBy=68472058812, createdName=日月生辉, createdTime=Wed Jul 12 08:00:59 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221173, encodeId=8e6e2211e326, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM7V1lG3lEERmrZh1ZAYgnIqsCAwFfLlOdXroVwBJqvTvw/0, createdBy=b2522082239, createdName=维维豆奶, createdTime=Tue Jul 11 22:52:04 CST 2017, time=2017-07-11, status=1, ipAttribution=)]
    2017-07-12 日月生辉

    新知识,学习了!

    0

  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Jul 12 16:22:43 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221332, encodeId=bde422133214, content=新知识,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYQJjaU2fLIb1yNqibkbdJs7gVIDr9xJyYeiapArSMjn3W61bPJtpIazSdAxRaFEOKYgfQjX4achN2d/0, createdBy=68472058812, createdName=日月生辉, createdTime=Wed Jul 12 08:00:59 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221173, encodeId=8e6e2211e326, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM7V1lG3lEERmrZh1ZAYgnIqsCAwFfLlOdXroVwBJqvTvw/0, createdBy=b2522082239, createdName=维维豆奶, createdTime=Tue Jul 11 22:52:04 CST 2017, time=2017-07-11, status=1, ipAttribution=)]
    2017-07-11 维维豆奶

    学习了

    0

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近期,上海交通大学药学院李大伟教授课题组经过多年研究在肿瘤治疗新靶点研究方面取得重大突破,其研究揭示了乳腺癌中高表达的人前梯度蛋白 2(AGR2)在肿瘤发生发展中的新作用机制。同时,根据相关机制开发的人源化抗体药物 Agtuzumab(18A4Hu)在抗肿瘤及药物联用方面也表现出了优良的治疗效果,相关的一系列研究发表在今年 5 月 8 日的 Nature 子刊《Oncogene》上以及 2016

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根据JAMA发表的两项研究,用甘精胰岛素U100 32周的治疗导致1型或2型糖尿病患者和低血糖危险因素中血糖下降(低血糖)发生率降低。

Diabetes:研究发现决定胰岛素释放量的“重要角色”!

胰腺中的专用β细胞释放激素胰岛素以控制我们的血糖水平,并且这种作用机制出现失败是2型糖尿病发展的核心原因。体内有多少胰岛素被释放取决于信使分子和蛋白质的复杂系统,这些系统目前尚未被完全研究清楚。

Diabetes Care:与BMI、葡萄糖和胰岛素敏感性相关的妊娠期代谢物!

近期,一项发表在杂志Diabetes Care上的研究使用孕妇的目标代谢组学比较了母体代谢物与母体BMI、血糖和胰岛素敏感性的关系。此项研究选自欧洲血统、非洲裔加勒比海地区、泰国人和墨西哥美籍的母亲(每个祖系谱选取400名)的空腹和1小时的血清葡萄糖,并进行临床代谢物、氨基酸和酰基肉碱的靶向代谢组学测定,这些受试者参与高血糖和不良妊娠结局(HAPO)研究,并在妊娠28周进行口服葡萄糖耐量试验。此项

注射胰岛素部位也要常轮换

随着糖尿病发病率的不断增高,注射胰岛素的糖友越来越多。长期注射胰岛素的糖友常会出现注射部位有硬块儿,这是注射胰岛素后产生局部硬结和皮下脂肪增生所致,是胰岛素治疗的常见并发症之一。注射部位的正确轮换是有效的预防方法,包括不同注射部位之间的轮换和同一注射部位内的...随着糖尿病发病率的不断增高,注射胰岛素的糖友越来越多。长期注射胰岛素的糖友常会出现注射部位有硬块儿,这是注射胰岛素后产生局部硬结和皮下脂

Neurology:2型糖尿病、血糖、胰岛素、体重指数和缺血性卒中亚型相关性分析!

由此可见,该研究支持T2D可能与大血管卒中存在因果关系。

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