JACC：持续性房扑和房颤的心房重塑比较

2020-07-22 MedSci原创 MedSci原创

房扑（AFL）和房颤（AF）与心房重构有关，但尚无任何实验研究涉及持续房扑的心房重构。这项研究旨在探究由持续性房扑（AFL）和/或房颤（AF）引起的心房重构。

房扑（AFL）和房颤（AF）与心房重构有关，但尚无任何实验研究涉及持续房扑的心房重构。这项研究旨在探究由持续性房扑（AFL）和/或房颤（AF）引起的心房重构。

本研究通过腔内射频损伤在狗上造房颤和房扑的模型，四组动物（每组6只狗）随访3周：持续性房扑，持续房颤（心律搏动600次/分钟）；房颤叠加房扑（AF + AFL）；窦性心律伴房扑（SR + AFL；对照组）。所有的狗均以80次/分钟的速度进行房室结消融和心室起搏器，以控制心室率。结果显示AFL，AF + AFL和AF的左房有效不应期缩短，而房颤组对额外刺激的脆弱性同时增加。诱发性房颤持续时间在AF + AFL和AF组中明显增加，而AFL组没有。与SR + AFL相比，AF + AFL和AF组的左房容积增加，但有AFL组则没有增加。光学测绘显示AF + AFL和AF组传导明显减慢，但AFL没有，同时也存在心房纤维化和胶原基因上调。左室功能在四组中无明显变化。

研究结果显示，持续性房扑会引起类似房颤的心房极性变化，但不会引起结构重塑。

原始出处：

Jean-B et al.Comparison of Atrial Remodeling Caused by Sustained Atrial Flutter Versus Atrial Fibrillation.JACC.2020 July.

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#插入话题

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2021-02-06 liuyg0228

#持续性#

93 0
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2020-09-02 hbwxf

#JACC#

87 0
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2020-10-15 苏小雨

学习了，不错

154 0
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2020-07-24 12498568m50暂无昵称

#ACC#

80 0
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2020-07-24 sodoo

#心房#

95 0
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2020-07-23 lovetcm

#房颤#

205 0
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2020-07-23 心介

房颤，临床上碰到很多哦

108 0
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2020-07-22 ms4000000967512513

受教了

132 0

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心血管

JACC：持续性房扑和房颤的心房重塑比较

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