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Diabetes Care:全身炎症反应综合症可区分糖尿病足感染程度

2013-09-29 佚名 丁香园

根据全身炎性反应综合症(SIRS),为了区分中、重度糖尿病足感染(DFI),来自美国匹兹堡大学医学中心治疗和预防截肢慈善中心的Wukich博士等人进行了一项研究,研究发现,SIRS可有效区分中、重度DFI住院患者。研究结果在线发表于2013年9月23日的美国《糖尿病治疗》(Diabetes Care)杂志上。【原文下载】 这是一项回顾性、单中心研究。研究人员对一个学术

根据全身炎性反应综合症(SIRS),为了区分中、重度糖尿病足感染(DFI),来自美国匹兹堡大学医学中心治疗和预防截肢慈善中心的Wukich博士等人进行了一项研究,研究发现,SIRS可有效区分中、重度DFI住院患者。研究结果在线发表于2013年9月23日的美国《糖尿病治疗》(Diabetes Care)杂志上。【原文下载】

这是一项回顾性、单中心研究。研究人员对一个学术性的脚踝项目数据库中的患者信息进行回顾分析,鉴定了119名患者。严重DFI定义为局部感染、伴有两处或多处客观的全身毒性表现(采用SIRS标准评价)。

结果显示,与中度DFI患者比较,严重DFI患者任何一种截肢术的风险高2.55倍,大切断术的风险高7.12倍。两组间小切断术风险没有显著差别(OR为1.02)。出现坏疽的患者发生严重DFI的可能性高7.82倍,而报告有厌食症、寒战、恶心或呕吐症状的患者发生严重DFI的可能性高5倍。严重DFI患者平均住院时间比中度DFI患者约多4天,区别具有统计学显著性。

研究发现,SIRS可有效区分中、重度DFI住院患者。严重DFI患者,主要表现为两处或多处全身炎症反应或毒性,与没有SIRS症状的患者比较,该类患者接受大切断术的比例较高,住院时间延长,需要进行多次手术和随后的更多入院时间。


原文下载

Wukich DK, Hobizal KB, Raspovic KM, Rosario BL.SIRS Is Valid in Discriminating Between Severe and Moderate Diabetic Foot Infections.Diabetes Care. 2013 Sep 23.


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