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我国非瓣膜病房颤患者用华法林抗凝治疗严重不足

2013-12-11 晓静 整理 医学论坛网

高鹏、方全和王佳丽等评估了我国非瓣膜病心房颤动(房颤)患者口服华法林抗凝(oral walfarin anticoagulation,OAC)治疗不足的状况并对其影响因素进行分析。 结果表明,我国非瓣膜病房颤患者中使用华法林抗凝治疗严重不足,且未能严格遵循血栓栓塞风险评估进行抗凝。相关论文在线发表于2013年第11期《中华心血管病杂志》。 本研究为单中心注册

高鹏、方全和王佳丽等评估了我国非瓣膜病心房颤动(房颤)患者口服华法林抗凝(oral walfarin anticoagulation,OAC)治疗不足的状况并对其影响因素进行分析。 结果表明,我国非瓣膜病房颤患者中使用华法林抗凝治疗严重不足,且未能严格遵循血栓栓塞风险评估进行抗凝。相关论文在线发表于2013年第11期《中华心血管病杂志》。

本研究为单中心注册研究,入选我院就诊的非瓣膜病房颤患者并登记其一般情况、疾病特征、合并疾患及抗凝治疗等,对患者进行CHA2DS2-VASc风险评分,评估我国房颤患者的抗凝状况并对华法林使用的影响原因进行单因素及多因素分析。

结果显示,全部入选的576例非瓣膜病房颤人群中,有214例(39.4%)OAC治疗,在476例药物治疗(非导管消融)的房颤患者中,144例(30.3%)例使用华法林抗凝。持续性房颤、糖尿病史、慢性心力衰竭史、缺血性卒中/一过性脑缺血发作史、CHA2DS2-VASc评分高者更多使用OAC治疗,合并冠心病的房颤患者由于更多用抗小板药物而较少OAC治疗。在多因素回归分析中,持续性房颤、慢性心衰史、缺血性卒中/一过性脑缺血发作史及非冠心病是使用OAC治疗的预测因子。 

论文标题:非瓣膜性心房颤动患者抗凝不足状况及原因分析


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