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Diabetes Care:高血压对糖尿病前期与心血管疾病风险之间关联的影响

2019-10-08 xing.T MedSci原创

由此可见,无论高血压状态如何,该人群中糖尿病前期与心血管疾病风险或全因死亡率增加均无关。

最近的研究表明仅在伴有高血压的个体中,糖尿病前期与心血管疾病(CVD)的风险增加有关。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员根据高血压状态分析了杰克逊心脏研究(JHS)中在基线时(2000-2004年)无糖尿病或有CVD病史的3313名黑人成年人糖尿病前期与CVD之间的相关性。

糖尿病前期定义为空腹血浆葡萄糖在100至125mg/dL之间或血红蛋白A1c在5.7至6.4%(39至46mmol/mol)之间。高血压定义为收缩压/舒张压≥140/90mmHg和/或自我报告使用降压药。研究人员随访了参与者的CVD事件和全因死亡率,直至2014年12月31日。

总体而言,JHS参与者中35%的参与者不存在糖尿病前期或高血压,仅18%的人处于糖尿病前期,仅22%的人患有高血压,以及25%的人都既处于糖尿病前期又患有高血压。与既不处于糖尿病前期又无高血压的参与者相比,仅处于糖尿病前期、仅患有高血压以及既处于糖尿病前期又有高血压的参与者发生CVD事件的多变量调整风险比分别为0.86(95%CI为0.51-1.45)、2.09(1.39-3.14)和1.93 (1.28-2.90)。在伴有和不伴有高血压的参与者中,糖尿病前期和CVD风险增加之间没有关联(分别为0.78[0.46-1.34]和0.94 [0.70-1.26])。不论是否患有高血压,糖尿病前期患者与全因死亡率之间均无关联。

由此可见,无论高血压状态如何,该人群中糖尿病前期与心血管疾病风险或全因死亡率增加均无关。 

原始出处:

Demetria Hubbard,et al.Prediabetes and Risk for Cardiovascular Disease by Hypertension Status in Black Adults: The Jackson Heart Study.Diabetes Care.2019.https://doi.org/10.2337/dc19-1074

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    2019-10-09 misszhang

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